Zusammenfassung
Riesenzelltumoren des Weichgewebes mit niedrig-malignem Potenzial („giant cell tumor of soft tissue“, GCT-ST) sind seltene primäre „Low-grade-Weichteilsarkome“. Das klinische Verhalten und die Histologie sind dem Riesenzelltumor des Knochens sehr ähnlich. Wir berichten über zwei GCT-ST-Fälle, die klinisch als Rezidiv einer anderen Tumorentität behandelt wurden. Die beiden voroperierten Tumoren waren ein hochdifferenziertes Leiomyosarkom des Weichgewebes und ein In-situ-Plattenepithelkarzinom der Haut. Das Auftreten von GCT-ST in chirurgischem Narbengewebe ist bisher noch nicht beschrieben und lässt an einen ätiologischen Zusammenhang zwischen reparativen Gewebeprozessen und dem Entstehen derartiger Läsionen denken. Die teils kurze Zeitspanne zwischen Operation und Auftreten des GCT-ST erscheint für die Entwicklung eines unabhängigen Zweittumors ungewöhnlich kurz, was die unscharfe Grenze zwischen reaktiven und neoplastischen fibrösen oder sogenannten fibrohistiozytären Läsionen unterstreicht.
Abstract
Giant cell tumor of soft tissue (GCT-ST) is a rare primary soft tissue tumor with low malignant potential. It is clinically and pathologically similar to the giant cell tumor of the bone. Two cases of GCT-ST in surgical scars are reported. Both tumors were initially regarded as tumor relapses of a leiomyosarcoma of deep soft tissue and a dermal in situ squamous cell carcinoma, respectively. The development of GCT-ST in surgical scars has not been observed previously. These findings suggest chronic inflammation and tissue repair as etiological factors in the development of GCT-ST. The period of time between initial surgical intervention and the development of the GCT-ST seems to be unusually short for the development of a “true” second neoplasm, which may underline the sometimes diffuse border between reactive “pseudosarcomatous” and neoplastic fibro-histiocytic lesions.
Literatur
Alex O, Wiethege T, Muller KM (1998) Myositis proliferans: eine pseudosarkomatöse Läsion im Weichgewebe. Pathologe 19:308–312
Beiner JM, Jokl P (2002) Muscle contusion injury and myositis ossificans traumatica. Clin Orthop Relat Res S110–S119
Calonje E (2000) Is cutaneous benign fibrous histiocytoma (dermatofibroma) a reactive inflammatory process or a neoplasm? Histopathology 37:278–280
De WI, Dal Cin P, Fletcher CD et al (2000) Cytogenetic, clinical and morphologic correlations in 78 cases of fibromatosis: a report from the CHAMP Study Group. Mod Pathol 13:1080–1085
Delpla PA, Rouge D, Durroux R et al (1998) Soft tissue tumors following traumatic injury: two observations of interest for the medicolegal causality. Am J Forensic Med Pathol 19:152–156
Folpe AL, Morris RJ, Weiss SW (1999) Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. Mod Pathol 12:894–902
Froehner M, Wirth MP (2001) Etiologic factors in soft tissue sarcomas. Onkologie 24:139–142
Fujita MQ, Hashida N, Shin M et al (1998) Clonal composition of malignant fibrous histiocytoma: analysis by PCR-based assay of the human androgen receptor gene (HUMARA). Oncology 55:600–606
Galed-Placed I, Garcia-Ureta E, Sanchez-Blas M, Lago-Novoa M (1998) Giant-cell tumor in soft parts in a patient with osseous Paget’s disease: diagnosis by fine-needle aspiration. Diagn Cytopathol 19:352–354
Grabellus F, von Winterfeld F, Sheu SY et al (2006) Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy. Virchows Arch 448:847–851
Green JJ, Heymann WR (2003) Dermatofibrosarcoma protuberans occurring in a smallpox vaccination scar. J Am Acad Dermatol 48:S54–S55
Guccion JG, Enzinger FM (1972) Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer 29:1518–1529
Kern WH (1960) Proliferative myositis; a pseudosarcomatous reaction to injury: a report of seven cases. Arch Pathol 69:209
Koizumi H, Mikami M, Doi M, Tadokoro M (2005) Clonality analysis of nodular fasciitis by HUMARA-methylation-specific PCR. Histopathology 47:320–321
Kowal-Vern A, Criswell BK (2005) Burn scar neoplasms: a literature review and statistical analysis. Burns 31:403–413
Leithner A, Weinhaeusel A, Zeitlhofer P et al (2005) Evidence of a polyclonal nature of myositis ossificans. Virchows Arch 446:438–441
Li M, Cordon-Cardo C, Gerald WL, Rosai J (1996) Desmoid fibromatosis is a clonal process. Hum Pathol 27:939–943
Lille S, Schnur P (2000) Malignant fibrous histiocytoma arising in a thoracotomy scar. Ann Plast Surg 45:74–77
Lucas DR, Shroyer KR, McCarthy PJ et al (1997) Desmoid tumor is a clonal cellular proliferation: PCR amplification of HUMARA for analysis of patterns of X-chromosome inactivation. Am J Surg Pathol 21:306–311
McLelland J, Chu T (1988) Dermatofibrosarcoma protuberans arising in a BCG vaccination scar. Arch Dermatol 124:496–497
Mentzel T, Calonje E, Fletcher CD (1994) Leiomyosarcoma with prominent osteoclast-like giant cells. Analysis of eight cases closely mimicking the so-called giant cell variant of malignant fibrous histiocytoma. Am J Surg Pathol 18:258–265
Nascimento AG (2002) Giant cell tumour of soft tissue. In: Fletcher CDM, Unni KK, Mertens F (eds) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC, Lyon, pp 118–119
O’Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE (2000) Giant cell tumors of soft tissue: a clinicopathologic study of 18 benign and malignant tumors. Am J Surg Pathol 24:386–395
Oliveira AM, Dei Tos AP, Fletcher CD, Nascimento AG (2000) Primary giant cell tumor of soft tissues: a study of 22 cases. Am J Surg Pathol 24:248–256
Salm R, Sissons HA (1972) Giant-cell tumours of soft tissues. J Pathol 107:27–39
Schwartz HS, Eskew JD, Butler MG (2002) Clonality studies in giant cell tumor of bone. J Orthop Res 20:387–390
Szendroi M (2004) Giant-cell tumour of bone. J Bone Joint Surg Br 86:5–12
Vanni R, Fletcher CD, Sciot R et al (2000) Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: a report of the CHAMP study group. Histopathology 37:212–217
Vogrincic GS, O’Connell JX, Gilks CB (1997) Giant cell tumor of tendon sheath is a polyclonal cellular proliferation. Hum Pathol 28:815–819
Wick MR, Mills SE, Ritter JH, Lind AC (1999) Postoperative/posttraumatic spindle cell nodule of the skin: the dermal analogue of nodular fasciitis. Am J Dermatopathol 21:220–224
Zelger BG, Zelger B (2001) Dermatofibroma (fibrous histiocytoma): an inflammatory or neoplastic disorder? Histopathology 38:379–381
Zuber TJ, Finley JL (1994) Nodular fasciitis. South Med J 87:842–844
Danksagung
Die Autoren möchten Herrn Prof. Dr. Detlef Katenkamp für die Mitbegutachtung beider Fälle herzlich danken.
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Grabellus, F., Sheu, SY., Schmidt, B. et al. Riesenzelltumoren des Weichgewebes (mit niedrig-malignem Potenzial) in Operationsnarben. Pathologe 30, 401–406 (2009). https://doi.org/10.1007/s00292-009-1142-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00292-009-1142-3