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Novel chlorhexidine dermal patches, preparation characterization and antimicrobial evaluation

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Abstract

The purpose of this work is to develop chlorhexidine dermal patches using Eudragit® RL100 as the patch forming polymer. Solvent casting technique was employed in the preparation of the patches. The prepared patches, the corresponding physical mixtures, and the individual ingredients were physicochemically characterized by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) to investigate drug-excipient interactions. The results of the incompatibility studies indicated that the drug was molecularly distributed in Eudragit RL100 matrix. The developed patches were evaluated in terms of tensile strength, percentage of elongation, patch weight, surface pH, content uniformity, and drug dissolution profile. The developed chlorhexidine-medicated patches were flexible, transparent, homogenous, elegant, and smooth. Evaluation of the antimicrobial activity of the developed patches showed effective antimicrobial action against varieties of microorganisms.

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Acknowledgements

The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding this Research Group No. RGP-299.

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Sayed H. Auda, Gamal M. Mahrous, Mohamed A. Ibrahim, Gamal A. Shazly & Mounir M. Salem-Bekhit

  2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

    Sayed H. Auda & Mohamed A. Ibrahim

  3. Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, 71526, Assiut, Egypt

    Gamal A. Shazly

  4. Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

    Mounir M. Salem-Bekhit

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  1. Sayed H. Auda
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  2. Gamal M. Mahrous
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  3. Mohamed A. Ibrahim
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  4. Gamal A. Shazly
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  5. Mounir M. Salem-Bekhit
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Correspondence to Sayed H. Auda.

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Auda, S.H., Mahrous, G.M., Ibrahim, M.A. et al. Novel chlorhexidine dermal patches, preparation characterization and antimicrobial evaluation. Polym. Bull. 74, 3995–4007 (2017). https://doi.org/10.1007/s00289-017-1935-0

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  • DOI: https://doi.org/10.1007/s00289-017-1935-0

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