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Relapse of acute promyelocytic leukemia in the external auditory canal confirmed by PML/RARA dual-fusion and RARA break-apart fluorescence in situ hybridization

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References

  1. Lo-Coco F, Avvisati G, Vignetti M, Breccia M, Gallo E, Rambaldi A, Paoloni F, Fioritoni G, Ferrara F, Specchia G, Cimino G, Diverio D, Borlenghi E, Martinelli G, Di Raimondo F, Di Bona E, Fazi P, Peta A, Bosi A, Carella AM, Fabbiano F, Pogliani EM, Petti MC, Amadori S, Mandelli F, Italian GCG (2010) Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group. Blood 116(17):3171–3179. https://doi.org/10.1182/blood-2010-03-276196

    Article  CAS  PubMed  Google Scholar 

  2. WY A, Chan GC, Chim CS, Shek TW, Ooi GC, Ho WK, Kwong YL (2001) Unusual sites of involvement by hematologic malignancies. Case 3. External auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide. J Clin Oncol 19(19):3993–3995. https://doi.org/10.1200/JCO.2001.19.19.3993

    Article  Google Scholar 

  3. Breccia M, Petti MC, Testi AM, Specchia G, Ferrara F, Diverio D, Romano A, Guerrisi V, Greco A, Fiorella ML, de Vincentiis M, Mandelli F, Lo Coco F (2002) Ear involvement in acute promyelocytic leukemia at relapse: a disease-associated ‘sanctuary’? Leukemia 16(6):1127–1130. https://doi.org/10.1038/sj.leu.2402497

    Article  CAS  PubMed  Google Scholar 

  4. Igarashi K, Hori T, Yamamoto M, Inazawa N, Noguchi H, Suzuki N, Somekawa Y, Sasaki M, Tsutsumi H, Hatakeyama N (2015) Extramedullary relapse in RARA rearrangement-negative acute promyelocytic leukemia successfully treated in combination with chemotherapy, local radiotherapy, and cord blood transplantation. J Pediatr Hematol Oncol 37(4):e234–e237. https://doi.org/10.1097/MPH.0000000000000293

    Article  PubMed  Google Scholar 

  5. Lafayette TC, Coser VM, Brule AO, Coser PL, Pereira WV (2010) External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature. J Pediatr Hematol Oncol 32(3):229–232. https://doi.org/10.1097/MPH.0b013e3181cf7ef3

    Article  PubMed  Google Scholar 

  6. Tobita T, Shinjyo K, Yanagi M, Takeshita A, Ohnishi K, Ohno R (1997) Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid. Intern Med 36(7):484–486. https://doi.org/10.2169/internalmedicine.36.484

    Article  CAS  PubMed  Google Scholar 

  7. Yagita M, Onishi R, Yamagata N, Shimazaki C, Kudoh H, Kobayashi M, Hikiji K, Konaka Y (1998) Extramedullary relapse in the external auditory canal in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid and autologous peripheral blood stem cell transplantation. Rinsho Ketsueki 39(9):709–715

    CAS  PubMed  Google Scholar 

  8. Burnett AK, Russell NH, Hills RK, Bowen D, Kell J, Knapper S, Morgan YG, Lok J, Grech A, Jones G, Khwaja A, Friis L, McMullin MF, Hunter A, Clark RE, Grimwade D, Group UKNCRIAMLW (2015) Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial. Lancet Oncol 16(13):1295–1305. https://doi.org/10.1016/S1470-2045(15)00193-X

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology, Tenri Hospital, 200 Mishima, Tenri, Nara, 632-8552, Japan

    Saki Minoda, Takashi Akasaka & Hitoshi Ohno

  2. Department of Otolaryngology, Tenri Hospital, Tenri, Japan

    Yusuke Okanoue

  3. Department of Diagnostic Pathology, Tenri Hospital, Tenri, Japan

    Gen Honjo

  4. Tenri Institute Medical Research, Tenri, Japan

    Miho Nakagawa & Hitoshi Ohno

Authors
  1. Saki Minoda
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  2. Takashi Akasaka
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  3. Yusuke Okanoue
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  4. Gen Honjo
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  5. Miho Nakagawa
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  6. Hitoshi Ohno
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Corresponding author

Correspondence to Takashi Akasaka.

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We obtained informed consent from the patient.

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The authors declare that there is no conflict of interest.

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Minoda, S., Akasaka, T., Okanoue, Y. et al. Relapse of acute promyelocytic leukemia in the external auditory canal confirmed by PML/RARA dual-fusion and RARA break-apart fluorescence in situ hybridization. Ann Hematol 97, 909–911 (2018). https://doi.org/10.1007/s00277-018-3235-7

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  • DOI: https://doi.org/10.1007/s00277-018-3235-7

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