Skip to main content

Advertisement

Log in

Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Zhao Z, Chen CC, Rillahan CD et al (2015) Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet 47:539–543

    Article  CAS  PubMed  Google Scholar 

  2. Zebisch A, Sill H (2008) Are mouthwashes a reliable source of constitutional DNA in patients with leukemia? Leuk Res 32:1164–1165

    Article  PubMed  Google Scholar 

  3. Zebisch A, Staber PB, Delavar A et al (2006) Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia. Cancer Res 66:3401–3408

    Article  CAS  PubMed  Google Scholar 

  4. Zebisch A, Haller M, Hiden K et al (2009) Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations. Leukemia 23:1049–1053

    Article  CAS  PubMed  Google Scholar 

  5. Zebisch A, Wolfler A, Fried I et al (2012) Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia. Leukemia 26:1842–1849

    Article  CAS  PubMed  Google Scholar 

  6. Wilke K, Duman B, Horst J (2000) Diagnosis of haploidy and triploidy based on measurement of gene copy number by real-time PCR. Hum Mutat 16:431–436

    Article  CAS  PubMed  Google Scholar 

  7. Cancer Genome Atlas Research Network (2013) Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 368:2059–2074

    Article  Google Scholar 

Download references

Funding

This work was supported by the Austrian Science Fund under Grant No. P 26619-B19 (to AZ). Work in the laboratories of AW, HS, and AZ is further supported by Leukämiehilfe Steiermark.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval and informed consent

This study was approved by the institutional review board of the Medical University of Graz, Austria, and was conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from all individual participants included in this study.

Authors’ contributions

OG and SH carried out the qPCR experiments, analyzed the data, and drafted the manuscript. KK and GH carried out NGS experiments, analyzed the data, and drafted the manuscript. AW and AZ reviewed the clinical data, performed statistical analyses, and drafted the manuscript. HS and AZ designed the study, analyzed the data and drafted the manuscript. All authors read and approved the final typescript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Armin Zebisch.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(DOC 141 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Geiger, O., Hatzl, S., Kashofer, K. et al. Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia. Ann Hematol 94, 1923–1924 (2015). https://doi.org/10.1007/s00277-015-2445-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-015-2445-5

Keywords

Navigation