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A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice

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Abstract

Objectives

To evaluate therapeutic outcomes of intraluminal brachytherapy (ILBT) for malignant obstructive jaundice (MOJ) against stent alone.

Methods

The PubMed, EMBASE, Cochrane Library, CNKI, Wan Fang, VIP and ClinicalTrials.gov databases were searched for all relevant comparative studies from the earliest available date up to 1 May 2017. Subgroup analyses were performed according to the type of study design and type of stent.

Results

Twelve studies that compared ILBT versus stent alone were eligible. A total of 641 participants with MOJ were included in our meta-analysis. A total of 340 participants were treated with intraluminal brachytherapy (ILBT); the other 301 participants were treated with biliary stent alone (stent group). ILBT was associated with lower risk of stent occlusion (OR 0.19; 95% CI 0.13–0.28; P < 0.00001) and better mean survival (MD = 3.15; 95% CI 2.64–3.66; P < 0.00001) compared with stent alone. However, the two groups were similar in number of complications (OR 0.84; 95% CI 0.45–1.56; P = 0.578), post-treatment reduced level of total bilirubin (TBIL) (MD = 22.71; 95% CI − 7.24–52.65; P = 0.14), post-treatment reduced level of direct bilirubin (DBIL) (MD = − 3.67; 95% CI − 14.09–6.75; P = 0.49), post-treatment reduced level of alanine aminotransferase (ALT) (MD = 21.09; 95% CI − 5.09–47.28; P = 0.11) and post-treatment reduced level of aspartate aminotransferase (AST) (MD = 20.86; 95% CI − 45.86–87.58; P = 0.54).

Conclusions

ILBT was significantly superior to stent alone in terms of stent occlusion and mean survival. Meanwhile, ILBT had comparable outcomes to stent alone in terms of complications and post-treatment reduced levels of TBIL, DBIL, ALT and AST. Therefore, ILBT may be considered a preferable technique for MOJ.

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Acknowledgements

Thanks are due to Jingjing Li, Juan Wu and Rui Zhu for assistance with the study and to Wenbin Ji for valuable discussion.

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Authors and Affiliations

  1. Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, Taizhou, 317000, Zhejiang Province, China

    Xinjian Xu, Jingjing Li, Juan Wu, Rui Zhu & Wenbin Ji

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  1. Xinjian Xu
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  2. Jingjing Li
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  3. Juan Wu
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  5. Wenbin Ji
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Correspondence to Wenbin Ji.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Xu, X., Li, J., Wu, J. et al. A Systematic Review and Meta-analysis of Intraluminal Brachytherapy Versus Stent Alone in the Treatment of Malignant Obstructive Jaundice. Cardiovasc Intervent Radiol 41, 206–217 (2018). https://doi.org/10.1007/s00270-017-1827-6

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