Skip to main content
Log in

Intra-arterial Autologous Bone Marrow Cell Transplantation in a Patient with Upper-extremity Critical Limb Ischemia

  • Case Report
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Induction of therapeutic angiogenesis by autologous bone marrow mononuclear cell transplantation has been identified as a potential new option in patients with advanced lower-limb ischemia. There is little evidence of the benefit of intra-arterial cell application in upper-limb critical ischemia. We describe a patient with upper-extremity critical limb ischemia with digital gangrene resulting from hypothenar hammer syndrome successfully treated by intra-arterial autologous bone marrow mononuclear cell transplantation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Tateishi-Yuyama E, Matsubara H, Murohara T et al (2002) Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360:427–435

    Article  PubMed  Google Scholar 

  2. Chochola M, Pytlík R, Kobylka P et al (2008) Autologous intra-arterial infusion of bone marrow mononuclear cells in patients with critical limb ischemia. Int Angiol 27:281–290

    PubMed  CAS  Google Scholar 

  3. Amann B, Luedemann C, Ratei R, Schmidt-Lucke JA (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Cell Transpl 18:371–380

    Article  Google Scholar 

  4. Comerota AJ, Lin A, Douville J, Burchardt ER (2010) Upper extremity ischemia treated with tissue repair cells from adult bone marrow. J Vasc Surg 52:723–729

    Article  PubMed  Google Scholar 

  5. Koshikawa M, Shimodaira S, Yoshioka T et al (2006) Therapeutic angiogenesis by bone marrow implantation for critical hand ischemia in patients with peripheral arterial disease: a pilot study. Curr Med Res Opin 22:793–798

    Article  PubMed  Google Scholar 

  6. Madaric J, Klepanec A, Mistrik M et al (2011) Autologous bone marrow cells transplantation in patients with advanced critical limb ischemia: no difference in intra-arterial and intramuscular application. JACC 57:E1473

    Article  Google Scholar 

  7. Chang BB, Roddy SP, Darling RC III et al (2003) Upper extremity bypass grafting for limb salvage in end-stage renal failure. J Vasc Surg 38:1313–1315

    Article  PubMed  Google Scholar 

  8. Procházka V, Gumulec J, Jalůvka F et al (2010) Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Cell Transpl 19:1413–1424

    Article  Google Scholar 

  9. Lara-Hernandez R, Lozano-Vilardell P, Blanes P et al (2010) Safety and efficacy of therapeutic angiogenesis as a novel treatment in patients with critical limb ischemia. Ann Vasc Surg 24:287–294

    Article  PubMed  CAS  Google Scholar 

  10. Miyamoto K, Nishigami K, Nagaya N et al (2006) Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114:2679–2684

    Article  PubMed  Google Scholar 

  11. Bartsch T, Brehm M, Zeus T et al (2007) Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study). Clin Res Cardiol 96:891–899

    Article  PubMed  CAS  Google Scholar 

  12. Zhou B, Poon MC, Pu WT, Han ZC (2007) Therapeutic neovascularisation for peripheral arterial disease: advances and perspectives. Histol Histopathol 22:677–686

    PubMed  CAS  Google Scholar 

  13. Sprengers RW, Lips DJ, Moll FL, Verhaar MC (2008) Progenitor cell therapy in patients with critical limb ischemia without surgical options. Ann Surg 247:411–420

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Juraj Madaric.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Madaric, J., Klepanec, A., Mistrik, M. et al. Intra-arterial Autologous Bone Marrow Cell Transplantation in a Patient with Upper-extremity Critical Limb Ischemia. Cardiovasc Intervent Radiol 36, 545–548 (2013). https://doi.org/10.1007/s00270-012-0415-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-012-0415-z

Keywords

Navigation