Skip to main content

Advertisement

Log in

Phlegmasia Caerulea Dolens in a Patient With an Inferior Vena Cava Filter: Treatment of Massive Iliocaval Thrombosis Using Local Intravenous Catheter-Directed Thrombolysis

  • Case Report
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Phlegmasia caerulea dolens (PCD) is a potentially disastrous complication of inferior vena cava filter insertion, and its optimum management has not been clearly established. We present a case report of a patient with pulmonary embolism and acute adrenal haemorrhage who developed PCD secondary to massive iliocaval thrombosis after insertion of a Cook Celect removable filter. Local intravenous catheter-directed thrombolysis (CDT), followed by systemic anticoagulation, achieved limb salvage and virtual resolution of symptoms at 3 months without complications. CDT can be a successful primary treatment of filter-associated PCD and can be safe in selected patients with acute nontraumatic haemorrhage. Systemic anticoagulation may subsequently restore complete venous patency and may therefore be a useful approach to postthrombolysis management of residual iliocaval thrombus when filter removal is indicated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Gregoire R (1983) La phlebite bleue (phlegmasia caerulea dolens). Presse Med 46:1313–1315

    Google Scholar 

  2. Chinsakchai K, Ten Duis K, Moll FL, de Borst GJ (2011) Trends in management of phlegmasia cerulea dolens. Vasc Endovasc Surg 45:5–14

    Article  Google Scholar 

  3. Aruny JE, Kandarpa K (1990) Phlegmasia cerulea dolens, a complication after placement of a bird’s nest vena cava filter. Am J Roentgenol 154:1105–1106

    CAS  Google Scholar 

  4. Martin JG, Marsh JL, Kresowik T (1995) Phlegmasia cerulea dolens: a complication of use of a filter in the vena cava. A case report. J Bone Joint Surg Am 77:452–454

    PubMed  CAS  Google Scholar 

  5. Shem K (2008) Phlegmasia cerulea dolens: rare complication of vena cava filter placement in man with paraplegia. J Spinal Cord Med 31:398–402

    PubMed  Google Scholar 

  6. Kawashima A, Sandler CM, Ernst RD et al (1999) Imaging of nontraumatic hemorrhage of the adrenal gland. Radiographics 19:949–963

    PubMed  CAS  Google Scholar 

  7. Streiff MB (2000) Vena caval filters: a comprehensive review. Blood 95:3669–3677

    PubMed  CAS  Google Scholar 

  8. Prevention du Risque d’Embolie Pulmonaire par Interruption Cave (2005) Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: The PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomised study. Circulation 112:416–422

    Article  Google Scholar 

  9. Turba UC, Arslan B, Meuse M et al (2010) Gunter tulip filter retrieval experience: predictors of successful retrieval. Cardiovasc Interv Radiol 33:732–738

    Article  Google Scholar 

  10. Elliot MS, Immelman EJ, Jeffery P et al (1979) The role of thrombolytic therapy in the management of phlegmasia cerulea dolens. Br J Surg 66:422–424

    Article  PubMed  CAS  Google Scholar 

  11. Nazir SA, Ganeshan A, Nazir S, Uberoi R (2009) Endovascular treatment options in the management of lower limb deep venous thrombosis. Cardiovasc Interv Radiol 32:861–876

    Article  Google Scholar 

  12. Tardy B, Moulin N, Mismetti P, Decousus H, Laporte S (2005) Intravenous thrombolytic therapy in patients with phlegmasia caerulea dolens. Haematologica 91:281–282

    Google Scholar 

  13. Garg SK, Yadav KS (1999) Developing venous gangrene in deep vein thrombosis: intra-arterial low-dose burst therapy with urokinase: case reports. Angiology 50:157–162

    Article  PubMed  CAS  Google Scholar 

  14. Patel NH, Plorde JJ, Meissner M (1998) Catheter-directed thrombolysis in the treatment of phlegmasia caerulea dolens. Ann Vasc Surg 12:471–475

    Article  PubMed  CAS  Google Scholar 

  15. Vedantham S, Vesely TM, Parti N et al (2003) Endovascular recanalization of the thrombosed filter-bearing inferior vena cava. J Vasc Interv Radiol 14:893–903

    Article  PubMed  Google Scholar 

  16. Ahmad I, Yeddula K, Wicky S, Kalva SP (2010) Clinical sequelae of thrombus in an inferior vena cava filter. Cardiovasc Interv Radiol 33:285–289

    Article  Google Scholar 

Download references

Conflict of interest

The authors declare no financial support or conflicts of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel Cookson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cookson, D., Caldwell, S. Phlegmasia Caerulea Dolens in a Patient With an Inferior Vena Cava Filter: Treatment of Massive Iliocaval Thrombosis Using Local Intravenous Catheter-Directed Thrombolysis. Cardiovasc Intervent Radiol 35, 1226–1230 (2012). https://doi.org/10.1007/s00270-011-0314-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00270-011-0314-8

Keywords

Navigation