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What is the Incidence of Biliary Carcinoma in Choledochal Cysts, When Do They Develop, and How Should it Affect Management?

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Abstract

The incidence of cancer in choledochal cysts (CCs) in adults was calculated to determine the timing and need for surgery. In 78 publications (1996–2010), 434 of 5780 reported CCs patients had cancer. Cholangiocarcinoma (70.4 %) and gallbladder cancer (23.5 %) were the most common malignancies. Only nine malignancies were reported before age 18 (0.42 %). In contrast, the incidence of malignancy in adults was 11.4 %. The median age for diagnosis of cancer was 42 years, and the incidence increased with each decade.

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The authors have no commercial associations or sources of support that might pose a conflict of interest. All authors have made substantive contributions to the study, and all authors endorse the data and conclusions.

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  1. Department of Surgery, Beth Israel Medical Center, New York, NY, USA

    Amit V. Sastry, Benjamin Abbadessa, Michael G. Wayne, Justin G. Steele & Avram M. Cooperman

  2. Pancreatic, Biliary and Liver Surgery of New York, Center for Digestive Health, 37 Union Square West, New York, NY, 10003, USA

    Amit V. Sastry

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Sastry, A.V., Abbadessa, B., Wayne, M.G. et al. What is the Incidence of Biliary Carcinoma in Choledochal Cysts, When Do They Develop, and How Should it Affect Management?. World J Surg 39, 487–492 (2015). https://doi.org/10.1007/s00268-014-2831-5

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