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Oral Isotretinoin in the Treatment of Postoperative Edema in Thick-Skinned Rhinoplasty: A Randomized Placebo-Controlled Clinical Trial

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  • Rhinoplasty
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Abstract

Background

The thick-skinned nose is still one of the most challenging aspects of rhinoplasty. The possible effects of oral isotretinoin on cosmetic results of rhinoplasty in patients with thick nasal skin have been considered during recent years.

Methods

In this double-blind placebo-controlled clinical trial, 48 cases were divided into two groups randomly. Oral isotretinoin (0.5-mg/kg) was started on the 31st day after surgery and given every other day for 1 month and after that daily for two additional months in the first group. The second group received a placebo in the same form, sequence and interval as the first group. The cosmetic results based on patient satisfaction and ranking by an expert surgeon were compared between the two groups at 3 months, 6 months and 1 year after surgery.

Results

Patient satisfaction and ranking by an expert surgeon in the isotretinoin group at 3 months and 6 months after surgery were significantly better than in the placebo group (p value < 0.05); however, at 12 months after surgery there was no statistically significant difference between the two groups (p value > 0.05).

Conclusion

Though postoperative use of oral isotretinoin in patients with thick nasal skin accelerates improvement in cosmetic results during the early months after surgery, it does not significantly affect the final cosmetic result 1 year after surgery.

Level of Evidence II

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Vali-Asr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Dr. Gharib Avenue, Keshavarz Boulevard, Tehran, Iran

    Amir A. Sazgar, Alireza Majlesi, Saeideh Shooshtari, Mohammad Sadeghi, Amir K. Sazgar & Amin Amali

Authors
  1. Amir A. Sazgar
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  2. Alireza Majlesi
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  3. Saeideh Shooshtari
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  4. Mohammad Sadeghi
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  5. Amir K. Sazgar
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  6. Amin Amali
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Corresponding author

Correspondence to Amir A. Sazgar.

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Sazgar, A.A., Majlesi, A., Shooshtari, S. et al. Oral Isotretinoin in the Treatment of Postoperative Edema in Thick-Skinned Rhinoplasty: A Randomized Placebo-Controlled Clinical Trial. Aesth Plast Surg 43, 189–195 (2019). https://doi.org/10.1007/s00266-018-1252-5

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  • DOI: https://doi.org/10.1007/s00266-018-1252-5

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