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Assessment of endothelial function and myocardial flow reserve using 15O-water PET without attenuation correction

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of 15O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and myocardial flow reserve (MFR) using 15O-water PET.

Methods

We retrospectively processed 70 consecutive 15O-water PET examinations obtained at rest and during cold pressor testing (CPT) in patients with dilated cardiomyopathy (n = 58), or at rest and during adenosine infusion in heart transplant recipients (n = 12). Data were reconstructed with attenuation correction (AC) and without attenuation correction (NAC) using filtered backprojection, and MBF was quantified using a single compartmental model. The agreement between AC and NAC data was assessed using Lin’s concordance correlation coefficient followed by Bland-Altman plot analysis.

Results

Regarding endothelial function, NAC PET showed poor reproducibility and poor agreement with AC PET data. Conversely, NAC PET demonstrated high reproducibility and a strong agreement with AC PET for the assessment of MFR.

Conclusion

Non-attenuation-corrected 15O-water PET provided an accurate measurement of MFR compared to attenuation-corrected PET. However, non-attenuation-corrected PET data were less effective for the assessment of endothelial function using CPT in this population.

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Acknowledgments

Sophie De Bouard, Brigitte David, Marie-Hermine Noel, Marie-Christine Onfroy, Christelle Lebouleux, Ahmed Abbas and Olivier Tirel are acknowledged for their technical assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Funding

This work was supported in part by an institutional grant from the Caen University Hospital (AOI 2008-09/089).

Statement of human rights

All examinations were performed as part of prospective investigations approved by our regional ethics committee (CPP Nord Ouest III), and all patients gave written informed consent before initial enrolment.

Author information

Authors and Affiliations

  1. Normandie Université, EA 4650, Caen, France

    Stéphane Tuffier, Damien Legallois, Michael Joubert, Alban Bailliez, Denis Agostini & Alain Manrique

  2. Department of Cardiology, Caen University Hospital, Caen, France

    Damien Legallois

  3. Department of Cardiac Surgery, Caen University Hospital, Caen, France

    Annette Belin

  4. Department of Cardiac Surgery, Rouen University Hospital, Rouen, France

    Michel Redonnet

  5. Department of Nuclear Medicine, Caen University Hospital, Caen, France

    Denis Agostini & Alain Manrique

  6. Cyceron PET Centre, Caen, France

    Alain Manrique

Authors
  1. Stéphane Tuffier
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  2. Damien Legallois
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  3. Annette Belin
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  4. Michael Joubert
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  5. Alban Bailliez
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  6. Michel Redonnet
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  7. Denis Agostini
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  8. Alain Manrique
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Corresponding author

Correspondence to Alain Manrique.

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Tuffier, S., Legallois, D., Belin, A. et al. Assessment of endothelial function and myocardial flow reserve using 15O-water PET without attenuation correction. Eur J Nucl Med Mol Imaging 43, 288–295 (2016). https://doi.org/10.1007/s00259-015-3163-x

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  • DOI: https://doi.org/10.1007/s00259-015-3163-x

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