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Hyperplastic callus formation in osteogenesis imperfecta type V: follow-up of three generations over ten years

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Abstract

Hyperplastic callus (HPC) formation is a prominent feature of osteogenesis imperfecta (OI) type V; however, little is known about its long-term outcome. In this case report we describe the occurrence, appearance and course of a femoral HPC in a patient with OI type V during 10 years of follow-up. Radiographs of HPC in this child were compared and contrasted with HPC formation in the femur of his father and paternal grandfather, who also were affected with OI type V. This case report makes it clear that HPC can lead to significant morbidity, not only in the acute phase but also long term as a result of residual alteration in bone architecture.

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Authors and Affiliations

  1. Genetics Unit, Shriners Hospital for Children and McGill University, Montreal, Quebec, Canada

    Moira S. Cheung, E. Michel Azouz, Francis H. Glorieux & Frank Rauch

  2. Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, H3G 1A6, Canada

    Frank Rauch

Authors
  1. Moira S. Cheung
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  2. E. Michel Azouz
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  3. Francis H. Glorieux
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  4. Frank Rauch
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Corresponding author

Correspondence to Frank Rauch.

Additional information

This study was supported by the Shriners of North America and the Fonds de la Recherche en Santé du Québec.

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Cheung, M.S., Azouz, E.M., Glorieux, F.H. et al. Hyperplastic callus formation in osteogenesis imperfecta type V: follow-up of three generations over ten years. Skeletal Radiol 37, 465–467 (2008). https://doi.org/10.1007/s00256-007-0441-0

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  • DOI: https://doi.org/10.1007/s00256-007-0441-0

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