Abstract
L-ficolin encoded by FCN2 gene is a crucial factor of defence against infection in humans. We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, Nganasans, Russians). We found a decreased prevalence of the rs17549193*T allele in all aboriginal populations as compared to Russians. Also, its frequency was the lowest in the Nenets among the studied populations, while frequency of the rs7851696*T allele was increased in this population. The results suggest that the Arctic populations of East Siberia are characterised by specificity of genetic make-up responsible for the activity of L-ficolin. Clinical and epidemiological studies are required to discover if these genetic features correlate with the infant infectious morbidity in East Siberian populations.
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The study was approved by the ethical committee of the Scientific Research Institute of Medical Problems of the North (# 9 of 8.09.2014). Signed informed consent was obtained from parents of all participated children.
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Russian Foundation for Basic Research, Government of Krasnoyarsk Territory, Krasnoyarsk Region Science and Technology Support Fund to the research project (16-44-240668)
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Smolnikova, M.V., Freidin, M.B. & Tereshchenko, S.Y. The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia. Immunogenetics 69, 409–413 (2017). https://doi.org/10.1007/s00251-017-0984-8
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DOI: https://doi.org/10.1007/s00251-017-0984-8