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Evaluation of Ventricular Septal Defect with Special Reference to the Spontaneous Closure Rate, Subaortic Ridge, and Aortic Valve Prolapse II

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Abstract

The medical records of 2283 patients with ventricular septal defect (VSD) were reviewed to determine spontaneous closure, left ventricular-to-right atrial shunt, subaortic ridge, and aortic valve prolapse. One thousand eight hundred and twenty-three patients had been followed 1 month to 26 years (median 4 years) by echocardiography. Most of 460 patients could not be followed due to transportation of the institution. VSD was perimembranous in 68.8% (1255), trabecular muscular in 21.7% (395), muscular outlet in 6% (109), muscular inlet in 2.6% (48), and doubly committed subarterial in 0.9% (16). Defect size was classified in 66.8% (1218) as small, in 15.7% (286) as moderate, and in 17.5% (319) as large. VSD closed spontaneously in 18.8% (343 of 1823 patients) by ages 40 days to 24.9 years (median, 1.8 years). One hundred fifty-seven of 1255 perimembranous defects (12.5%) and 167 of 395 trabecular muscular defects (42%) closed spontaneously (p < 0.001). Defect size became small in 306 (16.8%) of patients with VSD at a median of 2.5 years. Aneurysmal transformation was detected in 32.9% (600), left ventricular-to-right atrial shunt in 9.7% (176), subaortic ridge in 2.6% (48) of 1823 patients who were followed. In 381 (20.9%) of the 1823 patients, the VSD had been closed by a surgical or transcatheter technique. Surgery is required in one-fifth of patients with subaortic ridge or aortic valve prolapse. In conclusion, isolated VSDs are usually benign abnormalities that tend to shrink and close spontaneously.

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Authors and Affiliations

  1. Department of Paediatric Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Ayse Guler Eroglu, Sezen Ugan Atik, Irfan Levent Saltik & Funda Oztunc

  2. Department of Paediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Esma Sengenc

  3. Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Gulnaz Cig

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  1. Ayse Guler Eroglu
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  2. Sezen Ugan Atik
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  5. Irfan Levent Saltik
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Correspondence to Sezen Ugan Atik.

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Eroglu, A.G., Atik, S.U., Sengenc, E. et al. Evaluation of Ventricular Septal Defect with Special Reference to the Spontaneous Closure Rate, Subaortic Ridge, and Aortic Valve Prolapse II. Pediatr Cardiol 38, 915–921 (2017). https://doi.org/10.1007/s00246-017-1597-6

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  • DOI: https://doi.org/10.1007/s00246-017-1597-6

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