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QT Interval Prolongation Associated with the Oral Use of Domperidone in an Infant

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Abstract

Gastroesophageal reflux is very common in chilhood. If conservative procedures fail to relieve it, the use of a potent antiemetic agent that facilitates gastric motility and emptying, such as domperidone, is justified. We report a 4-month-old child who presented with QT interval prolongation after the oral use of domperidone, which normalized after the drug was discontinued.

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References

  1. JA Barone (1999) ArticleTitleDomperidone: a peripherally acting dopamine2-receptor antagonist Ann Pharmacother 33 429–440 Occurrence Handle10332535 Occurrence Handle1:CAS:528:DyaK1MXjtlyru70%3D

    PubMed  CAS  Google Scholar 

  2. E Bruera R Villamayor E Roca et al. (1986) ArticleTitleQT interval prolongation and ventricular fibrillation with IV domperidone Cancer Treat Rep 70 544–546

    Google Scholar 

  3. A Carroccio G Iacono G Montalto et al. (1994) ArticleTitleDomperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A double-blind randomized study versus placebo Scand J Gastroenterol 29 300–304 Occurrence Handle8047802 Occurrence Handle1:STN:280:ByuA38zms10%3D

    PubMed  CAS  Google Scholar 

  4. R Clara (1979) ArticleTitleChronic regurgitation and vomiting treated with domperidone. A multicenter evaluation Acta Paediatr Belg 32 203–207

    Google Scholar 

  5. B Drolet G Rousseau P Daleau R Cardinal J Turgeon (2000) ArticleTitleDomperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders Circulation 17 1883–1885

    Google Scholar 

  6. G Giaccone O Berletto Calciatia (1984) ArticleTitleTwo sudden deaths during prophylactic antiemetic treatment with high doses of domperidone and methylprednisolone Lancet 2 1336–1337 Occurrence Handle6150342 Occurrence Handle1:STN:280:BiqD2MbpslQ%3D

    PubMed  CAS  Google Scholar 

  7. M Glassman D George B Grill (1995) ArticleTitleGastroesophageal reflux in children. Clinical manifestations, diagnosis and therapy Gastroenterol Clin North Am 24 71–98 Occurrence Handle7729862 Occurrence Handle1:STN:280:ByqB2cjitlE%3D

    PubMed  CAS  Google Scholar 

  8. DA Gremse (2002) ArticleTitleGastroesophageal reflux disease in children: 200 an overview of pathophysiology, diagnosis, and treatment J Pediatr Gastroenterol Nutr 35 S297–S299 Occurrence Handle12607789

    PubMed  Google Scholar 

  9. MB Lewin RM Bryant AL Fenrich RG Grifka (1996) ArticleTitleCisapride-induced long QT interval J Pediatr 128 S279–S281

    Google Scholar 

  10. RJ Osborne ML Slevin RW Hunter et al. (1985) ArticleTitleCardiac arrhythmias during cytotoxic chemotherapy: role of domperidone Hum Toxicol 4 617–623 Occurrence Handle4077073 Occurrence Handle1:STN:280:BimD1czoslQ%3D

    PubMed  CAS  Google Scholar 

  11. N Quinn D Parkes G Jackson et al. (1985) ArticleTitleCardiotoxicity of domperidone [Letter] Lancet 2 724 Occurrence Handle2863702 Occurrence Handle1:STN:280:BiqB1MrgvVY%3D

    PubMed  CAS  Google Scholar 

  12. JB Roussak P Carey H Parrey (1984) ArticleTitleCardiac arrest after treatment with intravenous domperidone [Letter] Br Med J 289 1579 Occurrence Handle1:STN:280:DyaL2M%2FntlCqsw%3D%3D Occurrence Handle10.1136/bmj.289.6458.1579

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ecocenter, Hospital Socor, Belo Horizonte, MG, Brazil

    C.M.G. Rocha & M.M. Barbosa

  2. PUC Minas Gerais, Belo Horizonte, MG, Brazil

    M.M. Barbosa

Authors
  1. C.M.G. Rocha
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  2. M.M. Barbosa
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Correspondence to M.M. Barbosa.

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Rocha, C., Barbosa, M. QT Interval Prolongation Associated with the Oral Use of Domperidone in an Infant. Pediatr Cardiol 26, 720–723 (2005). https://doi.org/10.1007/s00246-004-0922-z

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  • DOI: https://doi.org/10.1007/s00246-004-0922-z

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