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A comparison of efficacy of doxazosin 4 and 8 mg in medical expulsive therapy of distal ureteral stones: a prospective randomized clinical trial

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Abstract

We aimed to investigate the efficacy of two different doses of doxazosin, 4 and 8 mg, in medical expulsive therapy (MET). This prospective randomized study included a total of 66 patients with distal ureteral stones which were radio-opaque and ≤10 mm. All patients were randomly divided into three groups: Group 1 included 25 patients receiving 4 mg doxazosin. Group 2 included 22 patients receiving 8 mg doxazosin. Diclofenac 100 mg p.o. and daily 1500–2000 cc hydration were advised to the patients in Groups 1 and 2 to relieve pain. Group 3 consisted of 19 patients who were defined as control group and received only hydration and analgesics. The mean age of the patients was 30 ± 7.6, 37.9 ± 11.5 and 33 ± 11.3 in Group 1, Group 2 and Group 3, respectively. The mean stone size was 6.6 ± 1.4, 7.1 ± 1.5 and 6.6 ± 1.5 in Group 1, Group 2 and Group 3, respectively. The stone expulsion rate of the patient groups was 18/25 (72 %), 15/22 (68.1 %) and 5/19 (25.3 %). There were significantly fewer pain episodes and lower analgesic requirement in Groups 1 and 2 (p = 0.021). However, the difference between Group 1 and Group 2 was non-significant (p = 0.207). Given the data of the present study, doxazosin, an alpha receptor blocker, exhibited equal efficacy with 4 or 8 mg doses in MET and was used safely and efficiently in ureteral stones <10 mm. The findings of the present study showed that 4 mg dose is effective, when doxazosin is preferred for MET.

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Acknowledgments

Thanks to Elzem Sen for final language revision.

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Authors and Affiliations

  1. Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

    Haluk Sen, Sakip Erturhan, Erkan Sadioglu, Omer Bayrak & İlker Seckiner

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  1. Haluk Sen
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  2. Sakip Erturhan
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  3. Erkan Sadioglu
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  4. Omer Bayrak
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  5. İlker Seckiner
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Correspondence to Haluk Sen.

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All the authors declare that they have no conflict of interest.

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All studies have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons gave their informed consent prior to their inclusion in the study. This article does not contain any studies with human participants or animals performed by any of the authors.

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Sen, H., Erturhan, S., Sadioglu, E. et al. A comparison of efficacy of doxazosin 4 and 8 mg in medical expulsive therapy of distal ureteral stones: a prospective randomized clinical trial. Urolithiasis 45, 461–464 (2017). https://doi.org/10.1007/s00240-016-0927-0

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  • DOI: https://doi.org/10.1007/s00240-016-0927-0

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