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Osteopenia/osteoporosis in patients with calcium nephrolithiasis

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Abstract

The objective of this study is to analyze the alterations in bone mineral density and bone and calcium–phosphorus metabolism in patients with calcium nephrolithiasis. We designed a study with 182 patients who were distributed among three groups: group O, 56 patients without nephrolithiasis; group A, 67 patients with calcium nephrolithiasis and mild lithogenic activity; and group B, 59 patients with calcium nephrolithiasis and severe lithogenic activity. Metabolic parameters of blood and urine that were related to calcium–phosphorous and bone metabolism and bone densitometry were assessed in all patients. A comparative study was performed on the variables of bone and calcium–phosphorus metabolism and bone densitometry as well as the presence or absence of osteopenia/osteoporosis. The patients in group B had a greater loss of bone mineral density, measured by the T-score, than the patients in groups O and A. Moreover, the proportion of patients in group B with osteopenia/osteoporosis was statistically significantly higher than the proportion of patients in groups O and A. We observed higher values of calciuria, fasting calcium/creatinine ratio, and 24-h calcium/creatinine among the patients in group B compared to the other two groups. Calciuria, citraturia, and fasting calcium/creatinine were independent factors that showed a relationship with severe lithogenic activity compared to the control group, and β-crosslaps is an independent factor that has a relationship with severe lithogenic activity as compared to mild lithogenic activity. Patients with calcium lithiasis and severe lithogenic activity have a greater loss in bone mineral density and therefore a greater risk of osteopenia/osteoporosis.

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Notes

  1. Determined by chemiluminescence methods in a LIAISON-Osteocalcin (DIASORIN) automatic analyzer.

  2. Determined by the “ECLIA” method, or electrochemiluminescence immunoassay, in an Elecsys MODULATOR ANALYTICS E170 automatic analyzer (Roche Diagnostics).

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Authors and Affiliations

  1. Urology Department, San Cecilio University Hospital, Camino de Ronda Street, 143. 4F, Granada, Spain

    Miguel Angel Arrabal-Polo, Miguel Arrabal-Martin & Armando Zuluaga-Gomez

  2. General Medicine, Granada, Spain

    Maria Sierra Girón-Prieto

  3. Biochemical Department, San Cecilio University Hospital, Granada, Spain

    Antonio Poyatos-Andujar

  4. Traumatology Department, San Cecilio University Hospital, Granada, Spain

    Juan Garrido-Gomez

  5. Medicine Department, Faculty of Medicine, Granada University, Granada, Spain

    Salvador Arias-Santiago

Authors
  1. Miguel Angel Arrabal-Polo
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  2. Miguel Arrabal-Martin
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  3. Maria Sierra Girón-Prieto
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  4. Antonio Poyatos-Andujar
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  5. Juan Garrido-Gomez
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  6. Armando Zuluaga-Gomez
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  7. Salvador Arias-Santiago
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Correspondence to Miguel Angel Arrabal-Polo.

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Arrabal-Polo, M.A., Arrabal-Martin, M., Girón-Prieto, M.S. et al. Osteopenia/osteoporosis in patients with calcium nephrolithiasis. Urol Res 40, 709–716 (2012). https://doi.org/10.1007/s00240-012-0497-8

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  • DOI: https://doi.org/10.1007/s00240-012-0497-8

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