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RETRACTED ARTICLE: A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients

  • Diagnostic Neuroradiology
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This article was retracted on 23 January 2016

Abstract

Introduction

The relationship between silent cerebral infarction (SCI) and the integrity of cognitive function is unknown. We intended to investigate whether cognitive impairment is associated with gray matter volume (GMV) in the SCI patients.

Methods

Sixty-two patients with SCI and 62 age- and gender-matched healthy controls (HC) were evaluated with P300 test, Montreal Cognitive Assessment (MoCA) test, Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HDRS). Whole brain high-resolution T1-weighted images were processed with SPM12b software and analyzed by voxel-based morphometry (VBM). Correlation analysis was performed between the GMV and the scores of MoCA Scale, P300 latency, P300 amplitude, HAMA, HDRS, age, and educational level.

Results

The brains of the SCI patients have a significant reduction in GMV in the left superior and inferior frontal gyrus, left superior temporal gyrus, right middle temporal gyrus, and bilateral hippocampus gyrus (p < 0.01, FDR correction). No significant increase of GMV was detected. The GMV of their frontal and temporal lobes is positively correlated with the score of MoCA scale and P300 amplitude (r ≥ 0.62, p < 0.01). The GMV of frontal, temporal, and hippocampus is negatively correlated with P300 latency (r ≤ −0.71, p < 0.05). No significant correlation between the GMV of abnormal brain regions and another two clinical characteristics was found.

Conclusion

SCI patients have impaired cognitive function and reduced GMV compared to the HC subjects. The neuropathological basis of such cognitive deficits in SCI patients might be a reduced GMV.

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Acknowledgements

This work was supported by the Study Guide project of Hubei Provincial Health Department (2011 JX5C12).

Ethical Standards and Patient Consent

We declare that all human and animal studies have been approved by the First Affiliated Hospital of Yangtze University, China, and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of Interest

We declare that we have no conflict of interest.

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Author notes

    Authors and Affiliations

    1. Biomedical Engineering Laboratory, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, People’s Republic of China

      Wei Luo, Xiaofeng Wei & Mengxiong Li

    2. Biomedical Engineering Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China

      Xun Jiang

    3. JingZhou City Central Blood Bank, 199 Jiangjin Middle Rd, Jingzhou, Hubei, People’s Republic of China, 434000

      Shanshan Li

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    1. Wei Luo
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    3. Xiaofeng Wei
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    Corresponding author

    Correspondence to Shanshan Li.

    Additional information

    Wei Luo and Xun Jiang contributed equally to this work.

    This article has been retracted by the authors due to the fact that it was published without permission and knowledge of the key authors of the study who published the same data in a different article (Yang T, Zhang L, Xiang M, Luo W, Huang J, Li M, Xiong X, Wang H. "Cognitive impairment and gray matter volume abnormalities in silent cerebral infarction" NeuroReport 2015 26(15):890-5.) The authors of both articles have reached an agreement to retract this article. The authors apologize to the Editors and readers as well as to all authors of the study.

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    Luo, W., Jiang, X., Wei, X. et al. RETRACTED ARTICLE: A study on cognitive impairment and gray matter volume abnormalities in silent cerebral infarction patients. Neuroradiology 57, 783–789 (2015). https://doi.org/10.1007/s00234-015-1535-3

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    • DOI: https://doi.org/10.1007/s00234-015-1535-3

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