Abstract
We describe two patients with symptomatic vasospasms after aneurysmal subarachnoid hemorrhage who were successfully treated with intraarterial injection of colforsin daropate hydrochloride (HCl). Colforsin daropate HCl is capable of directly stimulating adenylate cyclase, which in turn causes vasorelaxation via elevated intracellular concentrations of cyclic adenosine monophosphate. We suggest that colforsin daropate HCl might be a useful therapeutic tool in treating cerebral vasospasm.
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References
Allcock JM, Drake CG (1965) Ruptured intracranial aneurysms: the role of arterial spasm. J Neurosurg 22:21–29
Eskridge JM, Song JK (1997) A practical approach to the treatment of vasospasm. Am J Neuroradiol 18:1653–1660
Newell DW, Eskridge J, Mayberg MR et al (1989) Angioplasty for the treatment of symptomatic vasospasm following subarachnoid hemorrhage. J Neurosurg 71(5 Pt 1):654–660
Kaku Y, Yonekawa Y, Tsukahara T et al (1992) Superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg 77:842–847
Kassell NF, Helm G, Simmons N et al (1992) Treatment of cerebral vasospasm with intraarterial papaverine. J Neurosurg 77:848–852
Kallmes DF, Jensen ME, Dion JE (1997) Infusing doubt into the efficacy of papaverine. Am J Neuroradiol 18:263–264
Miller JA, Cross DT, Moran CJ et al (1995) Severe thrombocytopenia following intraarterial papaverine administration for treatment of vasospasm. J Neurosurg 83:435–437
Himeta M, Sakashita Y, Fujita A et al (1998) Characterization of the vasodilating effects of NKH477, a novel forskolin derivative, in isolated rat aortae, canine arteries and rabbit femoral arteries and veins. Jpn Pharmacol Ther 26:775–785
Ito S, Suzuki S, Itoh T et al (1993) Effects of a water-soluble forskolin derivative (NKH477) and a membrane-permeable cyclic AMP analogue on noradrenaline-induced Ca2+mobilization in smooth muscle of rabbit mesenteric artery. Br J Pharmacol 110:1117–1125
Shafiq J, Suzuki S, Itoh T et al (1992) Mechanisms of vasodilation induced by NKH477, a water-soluble forskolin derivative, in smooth muscle of the porcine coronary artery. Circ Res 71:70–81
Kamm KE, Stull JT (1989) Regulation of smooth muscle contractile elements by second messengers. Annu Rev Physiol 51:299–313
Onoue H, Kaito N, Akiyama M et al (1995) Altered reactivity of human cerebral arteries after subarachnoid hemorrhage. J Neurosurg 83:510–515
Arakawa Y, Kikuta K, Hoko M et al (2001) Milrinone for the treatment of cerebral vasospasm after subarachnoid hemorrhage: report of seven cases. Neurosurgery 48:723–730
Yoshida K, Watanabe H, Nakamura S (1997) Intraarterial injection of amrinone for vasospasm induced by subarachnoid hemorrhage. Am J Neuroradiol 18:492–496
Sutter B, Suzuki S, Arthur AS et al (1995) Effects of subarachnoid hemorrhage on vascular responses to calcitonin gene-related peptide and its related second messengers. J Neurosurg 83:516–521
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Suzuki, S., Ito, O., Sayama, T. et al. Intraarterial injection of colforsin daropate hydrochloride for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage: preliminary report of two cases. Neuroradiology 48, 50–53 (2006). https://doi.org/10.1007/s00234-005-0014-7
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DOI: https://doi.org/10.1007/s00234-005-0014-7