References
Khatami R, Tartarotti S, Siccoli MM, Bassetti CL, Sandor PS (2011) Long-term efficacy of sodium oxybate in 4 patients with chronic cluster headache. Neurology 77(1):67–70
Entholzner E, Mielke L, Pichlmeier R, Weber F, Schneck H (1995) EEG changes during sedation with gamma-hydroxybutyric acid. Der Anaesthesist 44(5):345–350
Brenneisen R, Elsohly MA, Murphy TP, Passarelli J, Russmann S, Salamone SJ, Watson DE (2004) Pharmacokinetics and excretion of gamma-hydroxybutyrate (GHB) in healthy subjects. J Anal Toxicol 28(8):625–630
Hechler V, Ratomponirina C, Maitre M (1997) gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide. J Pharmacol Exp Ther 281(2):753–760
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Weiss, T., Müller, D., Marti, I. et al. Gamma-hydroxybutyrate (GHB) and topiramate—clinically relevant drug interaction suggested by a case of coma and increased plasma GHB concentration. Eur J Clin Pharmacol 69, 1193–1194 (2013). https://doi.org/10.1007/s00228-012-1450-z
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DOI: https://doi.org/10.1007/s00228-012-1450-z