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Prevention of vancomycin induced nephrotoxicity: a review of preclinical data

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Abstract

Purpose

Several strategies have been proposed for the prevention of vancomycin-induced nephrotoxicity. Here, we review available evidence supporting the respective strategies.

Method

Data were collected by searching the Scopus, PubMed, and Medline databases and the Cochrane database of systematic reviews. The key words used as search terms were “vancomycin,” “nephrotoxicity”, “renal failure,” “renal damage,” “nephroprotective,” “renoprotective”, and “prevention.” Prospective or retrospective observational animal studies that evaluated the effects of a modality for the prevention of vancomycin-induced nephrotoxicity was included.

Results and conclusion

Animal studies show beneficial effects of various antioxidants, such as erdosteine, vitamin E, vitamin C, N-acetylcysteine, caffeic acid phenethyl ester, and erythropoietin, in the prevention of vancomycin-induced nephrotoxicity. However, before these agents can be used in clinical practice, their potential benefits must be confirmed in future randomized controlled human studies.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O.Box: 14155/6451, 1417614411, Tehran, Iran

    Sepideh Elyasi, Hossein Khalili, Shima Hatamkhani & Simin Dashti-Khavidaki

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  1. Sepideh Elyasi
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  2. Hossein Khalili
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  3. Shima Hatamkhani
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  4. Simin Dashti-Khavidaki
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Correspondence to Hossein Khalili.

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Elyasi, S., Khalili, H., Hatamkhani, S. et al. Prevention of vancomycin induced nephrotoxicity: a review of preclinical data. Eur J Clin Pharmacol 69, 747–754 (2013). https://doi.org/10.1007/s00228-012-1406-3

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  • DOI: https://doi.org/10.1007/s00228-012-1406-3

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