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Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis

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Abstract

Imbalances between bone formation and resorption are the primary cause of osteoporosis. However, currently, a detailed molecular mechanism of osteoporosis is not available. Autophagy is the conserved process characterized by degrading and recycling aggregated proteins, intracellular pathogens, and damaged organelles. MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes, including autophagy, through the posttranscriptional regulation of gene expression. Conversely, autophagy plays a role in the regulation of miRNA homeostasis. Recent advances have revealed that both autophagy and miRNAs are involved in the maintenance of bone homoeostasis, whereas the role of the interaction of miRNAs with autophagy in osteoporosis remains unclear. In this paper, we review previous reports on autophagy, miRNAs, and their interaction in osteoporosis.

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Funding

This study is supported by Natural Science Foundation of China [81503591], the Science and Technology Projects of Guangdong Province [2014A020221021], the Natural Science Foundation of Guangdong Province [2014A030310082], a Grant from Guangzhou University of Chinese Medicine for excellent Young Scholars Project [KAB110133K04], and the Disciplinary Construction Fund of Education Department in Guangdong Province for Young Researcher Project [2013LYM-0012].

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Authors and Affiliations

  1. Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    Gengyang Shen, Hui Ren, Ting Qiu & Zhida Zhang

  2. Department of Spinal Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    De Liang, Zhensong Yao, Zhidong Yang & Xiaobing Jiang

  3. The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    Bo Xie

  4. Laboratory Affiliated to National Key Discipline of Orthopaedic and Traumatology of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    Xiaobing Jiang

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  1. Gengyang Shen
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  9. Xiaobing Jiang
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Correspondence to Xiaobing Jiang.

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Gengyang Shen, Hui Ren, Ting Qiu, De Liang, Bo Xie, Zhida Zhang, Zhensong Yao, Zhidong Yang and Xiaobing Jiang declare that they have no conflict of interest.

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Shen, G., Ren, H., Qiu, T. et al. Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis. Calcif Tissue Int 99, 1–12 (2016). https://doi.org/10.1007/s00223-016-0122-x

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