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Magnetic immunochromatographic test for histamine detection in wine

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Abstract

Histamine, a biogenic amine, is abundant in fermented foods and beverages, notably wine. A high intake of this monoamine may produce adverse reactions in humans, which may be severe in individuals with a reduced capacity to catabolise extrinsic histamine. Thus, control of histamine concentration during wine production and before distribution is advisable. Simple, rapid, point-of-use bioanalytical platforms are needed because traditional methods for the detection and quantification of histamine are expensive and time-consuming. This work applies the lateral flow immunoassay technique to histamine detection. Superparamagnetic particle labels, and an inductive sensor designed to read the test line in the immunoassay, enable magnetic quantification of the molecule. The system is calibrated with histamine standards in the interval of interest for wine production. A commercial optical strip reader is used for comparison measurements. The lateral flow system has a limit of detection of 1.2 and 1.5 mg/L for the inductive and optical readers, respectively. The capability of the inductive system for histamine quantification is demonstrated for wine samples at different processing points (at the end of alcoholic fermentation, at the end of malolactic fermentation, in freshly bottled wine, and in reserve wine). The results are validated by ultra-high-performance liquid chromatography.

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Acknowledgements

Wine samples were kindly provided by Juan M. Redondo from DOP Vino de Cangas. The authors acknowledge the technical assistance of Begoña Redruello (IPLA) in the chromatographic analysis in wine samples.

Funding

This work was financially supported by the Spanish Ministry of Economy and Competitiveness under projects MAT2017-84959-C2-1-R, MAT2016-81955-REDT, and AGL2016-78708-R; the Council of Gijón-IUTA under grant SV-18-GIJON-1-27; and the Principality of Asturias under project IDI/2018/000185.

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Authors and Affiliations

  1. Department of Physical and Analytical Chemistry, University of Oviedo, c/ Julián Clavería 8, 33006, Oviedo, Spain

    Amanda Moyano & M. Carmen Blanco-López

  2. Department of Physics, University of Oviedo, 33204, Gijón, Spain

    Amanda Moyano, María Salvador, José C. Martínez-García & Montserrat Rivas

  3. Institute of Structure of Matter (CNR), 00015, Monterotondo Scalo, RM, Italy

    María Salvador & Davide Peddis

  4. Laboratory of Magnetic Fluids, Center for Fundamental and Advanced Technical Research, Romanian Academy - Timisoara Branch, 300223, Timisoara, Romania

    Vlad Socoliuc & Ladislau Vékás

  5. Dairy Research Institute of Asturias, IPLA (CSIC), Paseo Río Linares s/n, 33300, Villaviciosa, Asturias, Spain

    Miguel A. Alvarez & María Fernández

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  1. Amanda Moyano
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  2. María Salvador
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  3. José C. Martínez-García
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  4. Vlad Socoliuc
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  7. Miguel A. Alvarez
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  9. Montserrat Rivas
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  10. M. Carmen Blanco-López
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Correspondence to Montserrat Rivas or M. Carmen Blanco-López.

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Published in the topical collection Nanoparticles for Bioanalysis with guest editors María Carmen Blanco-López and Montserrat Rivas.

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Moyano, A., Salvador, M., Martínez-García, J.C. et al. Magnetic immunochromatographic test for histamine detection in wine. Anal Bioanal Chem 411, 6615–6624 (2019). https://doi.org/10.1007/s00216-019-02031-6

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  • DOI: https://doi.org/10.1007/s00216-019-02031-6

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