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Novel nanomaterials used for sample preparation for protein analysis

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Abstract

Sample preparation is of vital importance for proteomic analysis because of the high complexity of biological samples. The rapid development of novel nanomaterials with various compositions, morphologies, and proper surface modifications provides a category of powerful tools for the sample preparation for protein analysis. In this paper, we have summarized recent progresses for the applications of novel nanomaterials in sample preparation for the analysis of proteomes, especially for phosphoproteomes, glycoproteomes, and peptidoms. Several kinds of novel nanomaterials were also discussed for their use in other kinds of proteomics analysis.

Illustration of sample preparation methods by nanomaterials for protein analysis

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Abbreviations

Ag NPs:

Silver nanoparticles

APBA:

Aminophenylboronic acid

ATP:

Adenosine tri-phosphate

Au NPs:

Gold nanoparticles

Au NRs:

Gold nanorods

BMA:

N-butyl methacrylate

BSA:

Bovine serum albumins

CSCNTs:

Stacked-cup carbon nanotubes

DSS:

Suberic acid bis(N-hydroxysuccinimide ester)

DTT:

Dithiothreitol

ESI:

Electrospray ionization

HFMPs:

Hydrazine-functionalized magnetic particles

HILIC:

Hydrophilic interaction liquid chromatography

HMNs:

Hollow mesoporous nanospheres

HMS:

Hexagonal mesoporous silica

HSBF:

Hexa(sulfonbutyl) fullerene

IDA:

Iminodiacetate

IMAC:

Immobilized metal ion affinity chromatography

LLME:

Liquid-liquid microextraction

LMWP:

Low-molecular weight proteome

MALDI:

Matrix assisted laser desorption/ionization

MCNC:

Magnetic colloid nanocrystal cluster

MEONP:

P-nitrophenyloxycarbonyl polyethyleneglycol methacrylate

MNPs:

Magnetic nanoparticles

MOAC:

Metal oxide affinity chromatography

MPBA:

Mercaptophenylboronic acid

MPC:

Methacryloyloxyethyl phosphorylcholine

MS:

Mass spectrometry

MW:

Molecular weight

ND:

Nanodiamond

NTA:

Nitrilotriacetate

o-MWCNTs:

Oxidized multiwalled carbon nanotubes

PDDA:

Polyelectrolyte poly(diallyldimethylammonium chloride

PEGMP:

Poly(ethylene glycol methacrylate phosphate)

PEI:

Polyethylenimine

PLA:

Poly(L-lactic acid)

PMAA:

Poly(methylacrylic acid)

PMMA:

Polymethyl methacrylate

PNIPAAM:

Poly(N-isopropylacrylamide)

PTMs:

Post-transitional modifications

SAM:

Self-assembled monolayer

SELDI:

Surface enhanced laser desorption/ionization

TBA:

Teamed boronate affinity

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (21175008, 21322505, and 21027012) and The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Liping Li, Linnan Xu, Ze Li, Yu Bai & Huwei Liu

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  1. Liping Li
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  2. Linnan Xu
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  3. Ze Li
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Correspondence to Yu Bai.

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Li, L., Xu, L., Li, Z. et al. Novel nanomaterials used for sample preparation for protein analysis. Anal Bioanal Chem 406, 35–47 (2014). https://doi.org/10.1007/s00216-013-7392-1

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