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Synthesis and theoretical study of molecularly imprinted monoliths for HPLC

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Abstract

Molecularly imprinted monoliths integrate the high permeability of monolithic materials and the high selectivity and affinity of molecularly imprinted polymers (MIP). Thus, in recent years, development of this novel MIP format in HPLC has expanded quickly, particularly use of organic materials. This review focuses on the principal aspects of good practice in polymerization, theoretical studies, and recent developments in molecularly imprinted monoliths. Some thoughts on perspectives of MIP monoliths are also expressed.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant no. 21075090) and the Hundreds Talents Program of the Chinese Academy of Sciences.

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Authors and Affiliations

  1. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China

    Chao Zheng, Yan-Ping Huang & Zhao-Sheng Liu

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  1. Chao Zheng
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  2. Yan-Ping Huang
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  3. Zhao-Sheng Liu
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Correspondence to Yan-Ping Huang or Zhao-Sheng Liu.

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Published in the topical collection Monolithic Columns in Liquid Phase Separations with guest editor Luis A. Colon.

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Zheng, C., Huang, YP. & Liu, ZS. Synthesis and theoretical study of molecularly imprinted monoliths for HPLC. Anal Bioanal Chem 405, 2147–2161 (2013). https://doi.org/10.1007/s00216-012-6639-6

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  • DOI: https://doi.org/10.1007/s00216-012-6639-6

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