Analytical and Bioanalytical Chemistry

, Volume 405, Issue 9, pp 2931–2941

Influence of precursor solvent extraction on stable isotope signatures of methylamphetamine prepared from over-the-counter medicines using the Moscow and Hypophosphorous routes

  • Niamh NicDaéid
  • Saravana Jayamana
  • William J. Kerr
  • Wolfram Meier-Augenstein
  • Helen F. Kemp
Original Paper

DOI: 10.1007/s00216-012-6600-8

Cite this article as:
NicDaéid, N., Jayamana, S., Kerr, W.J. et al. Anal Bioanal Chem (2013) 405: 2931. doi:10.1007/s00216-012-6600-8

Abstract

A number of methods of clandestine manufacture of methylamphetamine involve the extraction and subsequent reaction of pseudoephedrine hydrochloride with other essential chemicals. The precursor can be easily extracted from over-the-counter medication widely available in the UK and elsewhere. Essential chemicals such as iodine and red phosphorous are also readily available and can be extracted from iodine tinctures and matchboxes, respectively. This work reports the repetitive preparation of methylamphetamine using two popular routes (the Moscow and Hypophosphorous synthesis). The focus was on the extraction solvent used for isolation of the precursor chemical and any consequential isotopic variation which may arise in the final product. Six batches of methylamphetamine were prepared under precisely controlled conditions for each synthetic route and for each of three different precursor extraction solvents. Synthesis of the final product from laboratory grade precursor using the synthetic methods described was used as a template for comparison. The resultant IRMS data from all 48 prepared samples suggests some underlying trends in the identification of the synthetic route which may aid in the interpretation of IRMS data derived from clandestine samples.

Keywords

Precursor Solvent extraction IRMS Methylamphetamine 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Niamh NicDaéid
    • 1
  • Saravana Jayamana
    • 1
  • William J. Kerr
    • 2
  • Wolfram Meier-Augenstein
    • 3
    • 4
  • Helen F. Kemp
    • 3
  1. 1.Department of Pure and Applied Chemistry, Centre for Forensic ScienceUniversity of StrathclydeGlasgowUK
  2. 2.Department of Pure and Applied Chemistry, WestCHEMUniversity of StrathclydeGlasgowUK
  3. 3.Stable Isotope Forensics LaboratoryJames Hutton InstituteInvergowrie, DundeeUK
  4. 4.Environmental and Forensic Science GroupRobert Gordon UniversityAberdeenUK