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Influence of precursor solvent extraction on stable isotope signatures of methylamphetamine prepared from over-the-counter medicines using the Moscow and Hypophosphorous routes

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Abstract

A number of methods of clandestine manufacture of methylamphetamine involve the extraction and subsequent reaction of pseudoephedrine hydrochloride with other essential chemicals. The precursor can be easily extracted from over-the-counter medication widely available in the UK and elsewhere. Essential chemicals such as iodine and red phosphorous are also readily available and can be extracted from iodine tinctures and matchboxes, respectively. This work reports the repetitive preparation of methylamphetamine using two popular routes (the Moscow and Hypophosphorous synthesis). The focus was on the extraction solvent used for isolation of the precursor chemical and any consequential isotopic variation which may arise in the final product. Six batches of methylamphetamine were prepared under precisely controlled conditions for each synthetic route and for each of three different precursor extraction solvents. Synthesis of the final product from laboratory grade precursor using the synthetic methods described was used as a template for comparison. The resultant IRMS data from all 48 prepared samples suggests some underlying trends in the identification of the synthetic route which may aid in the interpretation of IRMS data derived from clandestine samples.

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Authors and Affiliations

  1. Department of Pure and Applied Chemistry, Centre for Forensic Science, University of Strathclyde, 204 George Street, Glasgow, G1 1XW, UK

    Niamh NicDaéid & Saravana Jayamana

  2. Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK

    William J. Kerr

  3. Stable Isotope Forensics Laboratory, James Hutton Institute, Invergowrie, Dundee, DD2 5DA, UK

    Wolfram Meier-Augenstein & Helen F. Kemp

  4. Environmental and Forensic Science Group, Robert Gordon University, Aberdeen, AB10 1FR, UK

    Wolfram Meier-Augenstein

Authors
  1. Niamh NicDaéid
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  2. Saravana Jayamana
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  3. William J. Kerr
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  4. Wolfram Meier-Augenstein
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  5. Helen F. Kemp
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Corresponding author

Correspondence to Niamh NicDaéid.

Additional information

Published in the topical collection Isotope Ratio Measurements: New Developments and Applications with guest editors Klaus G. Heumann and Torsten C. Schmidt.

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NicDaéid, N., Jayamana, S., Kerr, W.J. et al. Influence of precursor solvent extraction on stable isotope signatures of methylamphetamine prepared from over-the-counter medicines using the Moscow and Hypophosphorous routes. Anal Bioanal Chem 405, 2931–2941 (2013). https://doi.org/10.1007/s00216-012-6600-8

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  • DOI: https://doi.org/10.1007/s00216-012-6600-8

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