Abstract
Rationale
Current psychotropic medications have been shown to modulate immune activation. However, the effects of individual psychotropic agents on the immune system and how these might contribute to their efficacy remain largely unclear.
Objective
This paper aims to review previous literature on the effects of antidepressants and antipsychotics on the immune system, with a systematic review of in vitro findings, and discuss the relevance of these effects for the response to treatment and future drug development.
Results
Inflammatory markers have been associated with fluctuations in clinical status and with treatment response both in depression and psychosis. The in vitro literature on antidepressants shows that some antidepressants, such as clomipramine and fluoxetine, more consistently decrease pro-inflammatory cytokines (interleukin (IL)-6, interferon (IFN)-γ, tumour necrosis factor (TNF)-α), whilst others (mirtazapine and venlafaxine) tend to increase their levels. However, any overall conclusion is challenged by several inconsistent findings, which appear partly dependent on different methodological approaches used. The in vitro studies on antipsychotics are even less clear-cut showing pro- and anti-inflammatory activity for the same antipsychotic agent (haloperidol, clozapine, risperidone) across different studies. We also noted inconsistencies between in vivo and in vitro literature, which could partly be attributed to the interaction in vivo with various biological systems or lifestyle factors that can modulate the immune system.
Conclusions
Inflammatory markers seem to hold potential for developing more individualised treatment strategies in the future. In this context, further research disentangling the differential immunomodulatory effects of different drugs could be used for tailoring treatment to specific individuals, according to their immune endophenotypes.
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References
André C, Dinel A-L, Ferreira G et al (2014) Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation. Brain Behav Immun 41:10–21. doi:10.1016/j.bbi.2014.03.012
Ayorech Z, Tracy DK, Baumeister D, Giaroli G (2014) Taking the fuel out of the fire: evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders. J Affect Disord 174C:467–478. doi:10.1016/j.jad.2014.12.015
Barrientos RM, Sprunger DB, Campeau S et al (2004) BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J Neuroimmunol 155:119–126. doi:10.1016/j.jneuroim.2004.06.009
Baumeister D, Lightman SL, Pariante CM (2014a) The interface of stress and the HPA axis in behavioural phenotypes of mental illness. Curr Top Behav Neurosci. doi:10.1007/7854_2014_304
Baumeister D, Russell A, Pariante CM, Mondelli V (2014b) Inflammatory biomarker profiles of mental disorders and their relation to clinical, social and lifestyle factors. Soc Psychiatry Psychiatr Epidemiol 49:841–849. doi:10.1007/s00127-014-0887-z
Baumeister D, Akhtar R, Ciufolini S et al (2015) Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry. doi:10.1038/mp.2015.67
Bleeker MWP, Netea MG, Kullberg BJ et al (1997) The effects of dexamethasone and chlorpromazine on tumour necrosis factor-α, interleukin-1β, interleukin-1 receptor antagonist and interleukin-10 in human volunteers. Immunology 91:548–552
Borges S, Gayer-Anderson C, Mondelli V (2013) A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis. Psychoneuroendocrinology 38:603–611. doi:10.1016/j.psyneuen.2012.12.025
Borsini A, Zunszain PA, Thuret S, Pariante CM (2015) The role of inflammatory cytokines as key modulators of neurogenesis. Trends Neurosci. doi:10.1016/j.tins.2014.12.006
Cairns KE, Yap MBH, Pilkington PD, Jorm AF (2014) Risk and protective factors for depression that adolescents can modify: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 169:61–75. doi:10.1016/j.jad.2014.08.006
Cannon TD, Chung Y, He G et al (2014) Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk. Biol Psychiatry 77:147–157. doi:10.1016/j.biopsych.2014.05.023
Carvalho LA, Juruena MF, Papadopoulos AS et al (2008) Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression. Neuropsychopharmacology 33:3182–3189. doi:10.1038/npp.2008.44
Carvalho LA, Garner BA, Dew T et al (2010) Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms. Eur Neuropsychopharmacol 20:379–387. doi:10.1016/j.euroneuro.2010.02.006
Cattaneo A, Gennarelli M, Uher R et al (2013) Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline “predictors” and longitudinal “targets”. Neuropsychopharmacology 38:377–385. doi:10.1038/npp.2012.191
Chen ML, Tsai TC, Lin YY et al (2011) Antipsychotic drugs suppress the AKT/NF-κB pathway and regulate the differentiation of T-cell subsets. Immunol Lett 140:81–91. doi:10.1016/j.imlet.2011.06.011
Chen E, Xu D, Lan X et al (2013a) A novel role of the STAT3 pathway in brain inflammation-induced human neural progenitor cell differentiation. Curr Mol Med 13:1474–1484
Chen M-L, Wu S, Tsai T-C et al (2013b) Regulation of macrophage immune responses by antipsychotic drugs. Immunopharmacol Immunotoxicol 35:573–580. doi:10.3109/08923973.2013.828744
Crampton SJ, Collins LM, Toulouse A et al (2012) Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation—a role for maternal inflammation? J Neurochem 120:964–973. doi:10.1111/j.1471-4159.2011.07634.x
Dahl J, Ormstad H, Aass HCD et al (2014) The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery. Psychoneuroendocrinology 45:77–86. doi:10.1016/j.psyneuen.2014.03.019
Dantzer R, O’Connor JC, Freund GG et al (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56. doi:10.1038/nrn2297
Dedon PC, Tannenbaum SR (2004) Reactive nitrogen species in the chemical biology of inflammation. Arch Biochem Biophys 423:12–22
Di Nicola M, Cattaneo A, Hepgul N et al (2013) Serum and gene expression profile of cytokines in first-episode psychosis. Brain Behav Immun 31:90–95. doi:10.1016/j.bbi.2012.06.010
Diamond M, Kelly JP, Connor TJ (2006) Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol 16:481–490. doi:10.1016/j.euroneuro.2005.11.011
Dickerson F, Stallings C, Origoni A et al (2007) C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophr Res 93:261–265. doi:10.1016/j.schres.2007.03.022
Dickerson F, Stallings C, Origoni A et al (2013) Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder. J Affect Disord 150:456–459. doi:10.1016/j.jad.2013.04.039
Dowlati Y, Herrmann N, Swardfager W et al (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67:446–457. doi:10.1016/j.biopsych.2009.09.033
Drzyzga L, Obuchowicz E, Marcinowska A, Herman ZS (2006) Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun 20:532–545. doi:10.1016/j.bbi.2006.02.002
Eller T, Vasar V, Shlik J, Maron E (2008) Pro-inflammatory cytokines and treatment response to escitalopram in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 32:445–450. doi:10.1016/j.pnpbp.2007.09.015
Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246:199–229. doi:10.1016/j.neuroscience.2013.04.060
Fornaro M, Martino M, Battaglia F et al (2011) Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation. Neuropsychiatr Dis Treat 7:51–56. doi:10.2147/NDT.S16382
Ganguli R, Yang Z, Shurin G et al (1994) Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Res 51:1–10. doi:10.1016/0165-1781(94)90042-6
Giovanoli S, Engler H, Engler A et al (2013) Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science 339:1095–1099. doi:10.1126/science.1228261
Grinberg YY, Dibbern ME, Levasseur VA, Kraig RP (2013) Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-α responses to spreading depression. J Neurochem 126:662–672. doi:10.1111/jnc.12267
Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 36:2452–2459. doi:10.1038/npp.2011.132
Hepgul N, Pariante CM, Dipasquale S et al (2012) Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychol Med 42:1893–1901. doi:10.1017/S0033291711002947
Hiles SA, Baker AL, de Malmanche T, Attia J (2012) Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis. Psychol Med 42:2015–2026. doi:10.1017/S0033291712000128
Himmerich H, Fulda S, Sheldrick AJ et al (2010) IFN-gamma reduction by tricyclic antidepressants. Int J Psychiatry Med 40:413–424. doi:10.2190/PM.40.4.e
Himmerich H, Schönherr J, Fulda S et al (2011) Impact of antipsychotics on cytokine production in-vitro. J Psychiatr Res 45:1358–1365. doi:10.1016/j.jpsychires.2011.04.009
Hinze-Selch D, Becker EW, Stein GM et al (1998) Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients. Neuropsychopharmacology 19:114–122. doi:10.1016/S0893-133X(98)00006-2
Howren MB, Lamkin DM, Suls J (2009) Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71:171–186. doi:10.1097/PSY.0b013e3181907c1b
Ida T, Hara M, Nakamura Y et al (2008) Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide. Neurosci Lett 432:232–236. doi:10.1016/j.neulet.2007.12.047
Johansson S, Price J, Modo M (2008) Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells 26:2444–2454. doi:10.1634/stemcells.2008-0116
Kiecolt-Glaser JK, Belury MA, Andridge R et al (2011) Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun 25:1725–1734. doi:10.1016/j.bbi.2011.07.229
Klemettilä J-P, Kampman O, Seppälä N et al (2014) Cytokine and adipokine alterations in patients with schizophrenia treated with clozapine. Psychiatry Res 218:277–283. doi:10.1016/j.psychres.2014.04.049
Köhler O, Benros ME, Nordentoft M et al (2014) Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects. JAMA Psychiatry 71:1381–1391. doi:10.1001/jamapsychiatry.2014.1611
Krause DL, Riedel M, Müller N et al (2012) Effects of antidepressants and cyclooxygenase-2 inhibitor on cytokines and kynurenines in stimulated in vitro blood culture from depressed patients. Inflammopharmacology 20:169–176. doi:10.1007/s10787-011-0112-6
Krause D, Weidinger E, Dippel C et al (2013) Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia. Psychiatr Danub 25:389–397
Kubera M, Kenis G, Budziszewska B et al (2001) Lack of a modulatory effect of imipramine on glucocorticoid-induced suppression of interferon- and interleukin-10 production in vitro. Pharmacol Rep 53:289–294
Kubera M, Kenis G, Basta-Kaim A et al (2002) Suppressive effect of TRH and antidepressants on human interferon-γ production in vitro. Acta Neuropsychiatr 14:226–230. doi:10.1034/j.1601-5215.2002.140505.x
Kubera M, Kenis G, Bosmans E et al (2004) Stimulatory effect of antidepressants on the production of IL-6. Int Immunopharmacol 4:185–192. doi:10.1016/j.intimp.2003.11.006
Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H (2000) Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 22:370–379. doi:10.1016/S0893-133X(99)00134-7
Lengacher CA, Kip KE, Barta M et al (2012) A pilot study evaluating the effect of mindfulness-based stress reduction on psychological status, physical status, salivary cortisol, and interleukin-6 among advanced-stage cancer patients and their caregivers. J Holist Nurs 30:170–185. doi:10.1177/0898010111435949
Leykin I, Mayer R, Shinitzky M (1997) Short and long term immunosuppressive effects of clozapine and haloperidol. Immunopharmacology 37:75–86. doi:10.1016/S0162-3109(97)00037-4
Lin A, Song C, Kenis G et al (2000) The in vitro immunosuppressive effects of moclobemide in healthy volunteers. J Affect Disord 58:69–74. doi:10.1016/S0165-0327(99)00076-2
Lucas M, Chocano-Bedoya P, Schulze MB et al (2014) Inflammatory dietary pattern and risk of depression among women. Brain Behav Immun 36:46–53. doi:10.1016/j.bbi.2013.09.014
MacDonald L, Hazi A, Paolini AG, Kent S (2014) Calorie restriction dose-dependently abates lipopolysaccharide-induced fever, sickness behavior, and circulating interleukin-6 while increasing corticosterone. Brain Behav Immun 40:18–26. doi:10.1016/j.bbi.2014.01.005
MacGillivray DM, Kollmann TR (2014) The role of environmental factors in modulating immune responses in early life. Front Immunol 5:434. doi:10.3389/fimmu.2014.00434
Maes M, Song C, Lin AH et al (1999) Negative immunoregulatory effects of antidepressants inhibition of interferon-γ and stimulation of interleukin-10 secretion. Neuropsychopharmacology 20:370–379. doi:10.1016/S0893-133X(98)00088-8
Maes M, Kenis G, Kubera M et al (2005) The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway. Int Immunopharmacol 5:609–618. doi:10.1016/j.intimp.2004.11.008
Manji HK, Chen G (2002) PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers. Mol Psychiatry 7(Suppl 1):S46–S56. doi:10.1038/sj.mp.4001018
Martinez JM, Garakani A, Yehuda R, Gorman JM (2012) Proinflammatory and “resiliency” proteins in the CSF of patients with major depression. Depress Anxiety 29:32–38. doi:10.1002/da.20876
Miller AH, Maletic V, Raison CL (2009) Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 65:732–741. doi:10.1016/j.biopsych.2008.11.029
Miller BJ, Buckley P, Seabolt W et al (2011) Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 70:663–671
Miller AH, Haroon E, Raison CL, Felger JC (2013) Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 30:297–306. doi:10.1002/da.22084
Mondelli V, Howes O (2014) Inflammation: its role in schizophrenia and the potential anti-inflammatory effects of antipsychotics. Psychopharmacology (Berl) 231:317–318. doi:10.1007/s00213-013-3383-3
Mondelli V, Cattaneo A, Belvederi Murri M et al (2011) Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. J Clin Psychiatry 72:1677–1684. doi:10.4088/JCP.10m06745
Mondelli V, Ciufolini S, Belvederi Murri M et al (2015) Cortisol and inflammatory biomarkers predict poor treatment response in first episode psychosis. Schizophr Bull. doi:10.1093/schbul/sbv028
Moots RJ, Al-Saffar Z, Hutchinson D et al (1999) Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines. Ann Rheum Dis 58:585–587. doi:10.1136/ard.58.9.585
Munkholm K, Vinberg M, Vedel Kessing L (2013) Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord 144:16–27. doi:10.1016/j.jad.2012.06.010
Munzer A, Sack U, Mergl R et al (2013) Impact of antidepressants on cytokine production of depressed patients in vitro. Toxins (Basel) 5:2227–2240. doi:10.3390/toxins5112227
Nanni V, Uher R, Danese A (2012) Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 169:141–151. doi:10.1176/appi.ajp.2011.11020335
Nitta M, Kishimoto T, Müller N et al (2013) Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials. Schizophr Bull 39:1230–1241. doi:10.1093/schbul/sbt070
Numao S, Sasai H, Nomata Y et al (2012) Effects of exercise training on circulating retinol-binding protein 4 and cardiovascular disease risk factors in obese men. Obes Facts 5:845–855. doi:10.1159/000346205
O’Brien SM, Scully P, Fitzgerald P et al (2007) Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatr Res 41:326–331. doi:10.1016/j.jpsychires.2006.05.013
O’Connell KE, Thakore J, Dev KK (2014) Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine. Schizophr Res 156:1–8. doi:10.1016/j.schres.2014.03.020
Pace TWW, Hu F, Miller AH (2007) Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun 21:9–19. doi:10.1016/j.bbi.2006.08.009
Pollmächer T, Hinze-Selch D, Mullington J (1996) Effects of clozapine on plasma cytokine and soluble cytokine receptor levels. J Clin Psychopharmacol 16:403–409
Potvin S, Stip E, Sepehry AA et al (2008) Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63:801–808. doi:10.1016/j.biopsych.2007.09.024
Raison C, Rutherford R (2013) A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA 70:31–41. doi:10.1001/2013.jamapsychiatry.4
Raison CL, Demetrashvili M, Capuron L, Miller AH (2005) Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 19:105–123. doi:10.1172/JCI29404.fundamental
Rosenkranz MA, Davidson RJ, Maccoon DG et al (2013) A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun 27:174–184. doi:10.1016/j.bbi.2012.10.013
Rudolf S, Peters M, Rothermundt M et al (2002) The influence of typical and atypical neuroleptic drugs in the production of interleukin-2 and interferon-gamma in vitro. Neuropsychobiology 46:180–185. doi:10.1159/000067807
Russell A, Ciufolini S, Gardner-Sood P et al (2015) Inflammation and metabolic changes in first episode psychosis: preliminary results from a longitudinal study. Brain Behav Immun. doi:10.1016/j.bbi.2015.06.004
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813:878–888. doi:10.1016/j.bbamcr.2011.01.034
Schwieler L, Larsson MK, Skogh E et al (2015) Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia—significance for activation of the kynurenine pathway. J Psychiatry Neurosci 40:126–133
Serafini G, Pompili M, Elena Seretti M et al (2013) The role of inflammatory cytokines in suicidal behavior: a systematic review. Eur Neuropsychopharmacol 23:1672–1686. doi:10.1016/j.euroneuro.2013.06.002
Sommer IE, van Westrhenen R, Begemann MJH et al (2014) Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update. Schizophr Bull 40:181–191. doi:10.1093/schbul/sbt139
Song C, Lin AH, Kenis G et al (2000) Immunosuppressive effects of clozapine and haloperidol: enhanced production of the interleukin-1 receptor antagonist. Schizophr Res 42:157–164
Song X, Fan X, Li X et al (2014) Changes in pro-inflammatory cytokines and body weight during 6-month risperidone treatment in drug naïve, first-episode schizophrenia. Psychopharmacology (Berl) 231:319–325. doi:10.1007/s00213-013-3382-4
Stojanovic A, Martorell L, Montalvo I et al (2014) Increased serum interleukin-6 levels in early stages of psychosis: associations with at-risk mental states and the severity of psychotic symptoms. Psychoneuroendocrinology 41:23–32. doi:10.1016/j.psyneuen.2013.12.005
Szuster-Ciesielska A, Tustanowska-Stachura A, Słotwińska M et al (2003) In vitro immunoregulatory effects of antidepressants in healthy volunteers. Pol J Pharmacol 55:353–362
Szuster-Ciesielska A, Słotwińska M, Stachura A et al (2004) Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers. Arch Immunol Ther Exp (Warsz) 52:59–67
Tourjman V, Kouassi É, Koué M-È et al (2013) Antipsychotics’ effects on blood levels of cytokines in schizophrenia: a meta-analysis. Schizophr Res 151:43–47. doi:10.1016/j.schres.2013.10.011
Tsai SY, Yang YY, Kuo CJ et al (2001) Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania. J Affect Disord 64:185–193
Tsai J-H, Kuo C-H, Yang P et al (2014) Effects of antidepressants on IP-10 production in LPS-activated THP-1 human monocytes. Int J Mol Sci 15:13223–13235. doi:10.3390/ijms150813223
Valkanova V, Ebmeier KP, Allan CL (2013) CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150:736–744. doi:10.1016/j.jad.2013.06.004
Viviani B, Boraso M, Valero M et al (2013) Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner. Brain Behav Immun 35:135–143. doi:10.1016/j.bbi.2013.09.008
Waiskopf N, Ofek K, Gilboa-Geffen A et al (2014) AChE and RACK1 promote the anti-inflammatory properties of fluoxetine. J Mol Neurosci 53:306–315. doi:10.1007/s12031-013-0174-6
Xia Z, DePierre JW, Nässberger L (1996) Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells. Immunopharmacology 34:27–37. doi:10.1016/0162-3109(96)00111-7
Yang J-J, Wang N, Yang C et al (2015) Serum interleukin-6 is a predictive biomarker for ketamine’s antidepressant effect in treatment-resistant patients with major depression. Biol Psychiatry 77:e19–e20. doi:10.1016/j.biopsych.2014.06.021
Zajkowska Z, Mondelli V (2014) First-episode psychosis: an inflammatory state? Neuroimmunomodulation 21:102–108. doi:10.1159/000356536
Zakharova M, Ziegler HK (2005) Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. J Immunol 175:5024–5033
Zautra AJ, Davis MC, Reich JW et al (2008) Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression. J Consult Clin Psychol 76:408–421. doi:10.1037/0022-006X.76.3.408
Zunszain PA, Anacker C, Cattaneo A et al (2011) Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuro-Psychopharmacology Biol Psychiatr 35:722–729. doi:10.1016/j.pnpbp.2010.04.011
Zunszain PA, Anacker C, Cattaneo A et al (2012) Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 37:939–949. doi:10.1038/npp.2011.277
Acknowledgments
This work was supported by the National Institute for Health Research Mental Health Biomedical Research Centre in Mental Health at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Conflict of interest
Dr. Mondelli has received research funding from Johnson & Johnson, a pharmaceutical company interested in the development of anti-inflammatory strategies for depression, but the research described in this paper is unrelated to this funding.
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Baumeister, D., Ciufolini, S. & Mondelli, V. Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment?. Psychopharmacology 233, 1575–1589 (2016). https://doi.org/10.1007/s00213-015-4044-5
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DOI: https://doi.org/10.1007/s00213-015-4044-5