Skip to main content

Advertisement

SpringerLink
Log in

Olanzapine attenuates cue-elicited craving for tobacco

  • Original Investigation
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rationale

Recent biological conceptualizations of craving and addiction have implicated mesolimbic dopamine activity as a central feature of the process of addiction. Imaging, and pharmacological studies have supported a role for dopaminergic structures in cue-elicited craving for tobacco.

Objective

If mesolimbic dopamine activity is associated with cue-elicited craving for tobacco, a dopamine antagonist should attenuate cue-elicited craving for tobacco. Thus, the aim of the present study was to determine whether an atypical antipsychotic (olanzapine, 5 mg) decreased cue-elicited craving for tobacco.

Method

Participants were randomly assigned to 5 days of pretreatment with olanzapine (5 mg; n=31) or were randomly assigned to 5 days of a matching placebo (n=28). Approximately 8 h after the last dose, participants were exposed to a control cue (pencil) followed by exposure to smoking cues. Participants subsequently smoked either nicotine cigarettes or de-nicotinized cigarettes.

Results

Olanzapine attenuated cue-elicited craving for tobacco but did not moderate the subjective effects of smoking.

Discussion

This study represents one of the first investigations of the effect of atypical antipsychotics on cue-elicited craving for tobacco. The results suggest that medications with similar profiles may reduce cue-elicited craving, which in turn, may partially explain recent observations that atypical antipsychotics may reduce substance use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28:309–369

    CAS  PubMed  Google Scholar 

  • Brauer LH, Cramblett MJ, Paxton DA, Rose JE (2001) Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. Psychopharmacology 159:31–37

    Article  CAS  PubMed  Google Scholar 

  • Butschky M, Bailey D, Henningfield JE, Pickworth WB (1995) Smoking without nicotine delivery decreases withdrawal in 12-h abstinent smokers. Pharmacol Biochem Behav 50:91–96

    CAS  PubMed  Google Scholar 

  • Carter BL, Tiffany ST (1999) Meta-analysis of cue-reactivity in addiction research [see comments]. Addiction 94:327–340

    CAS  PubMed  Google Scholar 

  • Caskey NH, Jarvik ME, Wirshing WC (1999) The effects of dopaminergic D2 stimulation and blockade on smoking behavior. Exp Clin Psychopharmacol 7:72–78

    Google Scholar 

  • Caskey NH, Jarvik ME, Wirshing WC, Madsen DC, Iwamoto-Schaap PN, Eisenberger NI, Huerta L, Terrace SM, Olmstead RE (2002) Modulating tobacco smoking rates by dopaminergic stimulation and blockade. Nicotine Tobacco Res 4:259–266

    Article  CAS  PubMed  Google Scholar 

  • Dallery J, Houtsmuller EJ, Pickworth WB, Stitzer ML (2003) Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking. Psychopharmacology 165:172–180

    CAS  PubMed  Google Scholar 

  • Dawe S, Gerada C, Russell MA, Gray JA (1995) Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117:110–115

    Google Scholar 

  • Del Boca FK, Kranzler HR, Brown J, Korner PF (1996) Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer. Alcohol Clin Exp Res 20:1412–1417

    PubMed  Google Scholar 

  • Drake RE, Xie H, McHugo GJ, Green AI (2000) The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia. Schizophr Bull 26:441–449

    CAS  PubMed  Google Scholar 

  • Due DL, Huettel SA, Hall WG, Rubin DC (2002) Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging. Am J Psychiatry 159:954–960

    Article  PubMed  Google Scholar 

  • Durcan MJ, Deener G, White J, Johnston JA, Gonzales D, Niaura R, Rigotti N, Sachs DP (2002) The effect of bupropion sustained-release on cigarette craving after smoking cessation. Clin Ther 24:540–551

    Article  CAS  PubMed  Google Scholar 

  • George TP, Ziedonis DM, Feingold A, Pepper WT, Satterburg CA, Winkel J, Rounsaville BJ, Kosten TR (2000) Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. Am J Psychiatry 157:1835–1842

    Article  CAS  PubMed  Google Scholar 

  • Goldstein MG (1999) Missed opportunities to assist hospitalized smokers. Am J Prev Med 17:317–318

    Article  CAS  PubMed  Google Scholar 

  • Green AI, Zimmet SV, Strous RD, Schildkraut JJ (1999) Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine? Harv Rev Psychiatry 6:287–296

    CAS  PubMed  Google Scholar 

  • Hutchison KE, Niaura R, Swift R (1999) Smoking cues decrease prepulse inhibition of the startle response and increase subjective craving in humans. Exp Clin Psychopharmacol 7:250–256

    Google Scholar 

  • Hutchison KE, Niaura R, Swift RM (2000) The effects of smoking high nicotine cigarettes on prepulse inhibition, startle latency, and subjective responses. Psychopharmacology 150:244–252

    Google Scholar 

  • Hutchison KE, Swift R, Rohsenow DJ, Monti PM, Davidson D, Almeida A (2001) Olanzapine reduces urge to drink after drinking cues and a priming dose of alcohol. Psychopharmacology 155:27–34

    Article  CAS  PubMed  Google Scholar 

  • Hutchison KE, LaChance H, Niaura R, Bryan AD, Smolen A (2002) The DRD4 VNTR poylmorphism influences reactivity to smoking cues. J Abnorm Psychol 111:134–143

    Article  PubMed  Google Scholar 

  • Hutchison KE, Wooden A, Swift RM, Smolen A, McGeary J, Adler L, Paris L (2003) Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction. Neuropsychopharmacology 28:1882–1888

    Article  CAS  PubMed  Google Scholar 

  • Lee ML, Dickson RA, Campbell M, Oliphant J, Gretton H, Dalby JT (1998) Clozapine and substance abuse in patients with schizophrenia. Can J Psychiatry 43:855–856

    CAS  PubMed  Google Scholar 

  • Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the biphasic alcohol effects scale. Alcohol Clin Exp Res 17:140–146

    CAS  PubMed  Google Scholar 

  • McEvoy JP, Freudenreich O, Levin ED, Rose JE (1995a) Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology 119:124–126

    CAS  PubMed  Google Scholar 

  • McEvoy J, Freudenreich O, McGee M, VanderZwaag C, Levin E, Rose J (1995b) Clozapine decreases smoking in patients with chronic schizophrenia. Biol Psychiatry 37:550–552

    Article  CAS  PubMed  Google Scholar 

  • Niaura R, Abrams DB (2002) Smoking cessation: progress, priorities, and prospectus. J Consult Clin Psychol 70:494–509

    Article  PubMed  Google Scholar 

  • Niaura RS, Rohsenow DJ, Binkoff JA, Monti PM, Pedraza M, Abrams DB (1988) Relevance of cue reactivity to understanding alcohol and smoking relapse. J Abnorm Psychol 97:133–152

    CAS  PubMed  Google Scholar 

  • Niaura R, Abrams DB, Pedraza M, Monti PM, Rohsenow DJ (1992) Smokers’ reactions to interpersonal interaction and presentation of smoking cues. Addict Behav 17:557–566

    CAS  PubMed  Google Scholar 

  • Niaura R, Shadel WG, Abrams DB, Monti PM, Rohsenow DJ, Sirota A (1998) Individual differences in cue reactivity among smokers trying to quit: effects of gender and cue type. Addict Behav 23:209–224

    CAS  PubMed  Google Scholar 

  • Pickworth WB, Fant RV, Nelson RA, Rohrer MS, Henningfield JE (1999) Pharmacodynamic effects of new de-nicotinized cigarettes. Nicotine Tobacco Res 1:357–364

    CAS  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247–291

    CAS  PubMed  Google Scholar 

  • Robinson M, Houtsmuller E, Moolchan ET, Pickworth WB (2000) Placebo cigarettes in smoking research. Exp Clin Psychopharmacol 8:326–332

    CAS  PubMed  Google Scholar 

  • Sayette MA, Hufford MR (1994) Effects of cue exposure and deprivation on cognitive resources in smokers. J Abnorm Psychol 103:812–818

    Article  CAS  PubMed  Google Scholar 

  • Sayette MA, Shiffman S, Tiffany ST, Niaura RS, Martin CS, Shadel WG (2000) The measurement of drug craving. Addiction 95:S189–S210

    PubMed  Google Scholar 

  • Sayette MA, Martin CS, Wertz JM, Shiffman S, Perrott MA (2001) A multi-dimensional analysis of cue-elicited craving in heavy smokers and tobacco chippers. Addiction 96:1419–1432

    Article  CAS  PubMed  Google Scholar 

  • Shiffman S, Paty JA, Gnys M, Kassel JA, Hickcox M (1996) First lapses to smoking: within-subjects analysis of real-time reports. J Consult Clin Psychol 64:366–379

    Google Scholar 

  • Shiffman S, Elash CA, Paton SM, Gwaltney CJ, Paty JA, Clark DB, Liu KS, Di Marino ME (2000a) Comparative efficacy of 24-hour and 16-hour transdermal nicotine patches for relief of morning craving. Addiction 95:1185–1195

    Article  CAS  PubMed  Google Scholar 

  • Shiffman S, Johnston JA, Khayrallah M, Elash CA, Gwaltney CJ, Paty JA, Gnys M, Evoniuk G, DeVeaugh-Geiss J (2000b) The effect of bupropion on nicotine craving and withdrawal. Psychopharmacology 148:33–40

    Google Scholar 

  • Shiffman S, Shadel WG, Niaura R, Moise KA, Jorenby DE, Ryan CF, Ferguson CL (2003) Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving. Psychopharmacology 166:343–350

    CAS  PubMed  Google Scholar 

  • Swift RM, Whelihan W, Kuznetsov O, Buongiorno G, Hsuing H (1994) Naltrexone-induced alterations in human ethanol intoxication. Am J Psychiatry 151:1463–1467

    PubMed  Google Scholar 

  • Tiffany ST (1990) A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97:147–168

    CAS  PubMed  Google Scholar 

  • Tiffany ST (1995) The role of cognitive factors in reactivity to drug cues. In: Drummond STTDC, Glautier S, Remington B (eds) Addictive behaviour: cue exposure theory and practice, vol 7. Wiley, New York, pp 137–165

  • Tiffany ST, Carter BL, Singleton EG (2000) Challenges in the manipulation, assessment and interpretation of craving relevant variables. Addiction 95:S177–S187

    PubMed  Google Scholar 

  • Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Person Soc Psychol 54:1063–1070

    CAS  PubMed  Google Scholar 

  • Wise RA (1988) The neurobiology of craving: implications for the understanding and treatment of addiction. J Abnorm Psychol 97:118–132

    CAS  PubMed  Google Scholar 

  • Zimmet SV, Strous RD, Burgess ES, Kohnstamm S, Green AI (2000) Effects of clozapine on substance use in patients with schizophrenia and schizoaffective disorder: a retrospective survey. J Clin Psychopharmacol 20:94–98

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported by grants from the Eli Lilly & Company and the National Cancer Institute (1R21CA81637) as well as grant 2 M01-RR00051 from the General Clinical Research Center Program of the National Center for Research Resources, National Institutes of Health.

Author information

Authors and Affiliations

  1. Department of Psychology, University of Colorado, Campus Box 345, Boulder, CO, 80309-0345, USA

    Kent E. Hutchison, Marie-Christine Rutter & Laura Sobik

  2. Centers for Behavioral Medicine, Providence, RI, USA

    Raymond Niaura

  3. Providence Veteran Affairs Medical Center and Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA

    Robert M. Swift

  4. Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA

    Wallace B. Pickworth

Authors
  1. Kent E. Hutchison
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie-Christine Rutter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Raymond Niaura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert M. Swift
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wallace B. Pickworth
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Laura Sobik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kent E. Hutchison.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hutchison, K.E., Rutter, MC., Niaura, R. et al. Olanzapine attenuates cue-elicited craving for tobacco. Psychopharmacology 175, 407–413 (2004). https://doi.org/10.1007/s00213-004-1837-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-004-1837-3

Keywords

Search

Navigation