Short Communication

Archives of Toxicology

, Volume 87, Issue 4, pp 763-766

Induction of skin sensitization is augmented in Nrf2-deficient mice

  • Jochem W. van der VeenAffiliated withDepartment of Toxicogenomics, Maastricht UniversityLaboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM) Email author 
  • , Eric R. GremmerAffiliated withLaboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM)
  • , Jolanda P. VermeulenAffiliated withLaboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM)
  • , Henk van LoverenAffiliated withDepartment of Toxicogenomics, Maastricht UniversityLaboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM)
  • , Janine EzendamAffiliated withLaboratory for Health Protection Research (GBO), National Institute for Public Health and the Environment (RIVM)

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Abstract

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

Keywords

Skin sensitization LLNA Nrf2-deficient In vivo