Induction of skin sensitization is augmented in Nrf2-deficient mice
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- van der Veen, J.W., Gremmer, E.R., Vermeulen, J.P. et al. Arch Toxicol (2013) 87: 763. doi:10.1007/s00204-012-0976-2
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Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.