Archives of Toxicology

, Volume 87, Issue 4, pp 763–766

Induction of skin sensitization is augmented in Nrf2-deficient mice

  • Jochem W. van der Veen
  • Eric R. Gremmer
  • Jolanda P. Vermeulen
  • Henk van Loveren
  • Janine Ezendam
Short Communication

DOI: 10.1007/s00204-012-0976-2

Cite this article as:
van der Veen, J.W., Gremmer, E.R., Vermeulen, J.P. et al. Arch Toxicol (2013) 87: 763. doi:10.1007/s00204-012-0976-2

Abstract

Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.

Keywords

Skin sensitizationLLNANrf2-deficientIn vivo

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jochem W. van der Veen
    • 1
    • 2
  • Eric R. Gremmer
    • 2
  • Jolanda P. Vermeulen
    • 2
  • Henk van Loveren
    • 1
    • 2
  • Janine Ezendam
    • 2
  1. 1.Department of ToxicogenomicsMaastricht UniversityMaastrichtThe Netherlands
  2. 2.Laboratory for Health Protection Research (GBO)National Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands