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ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (EOs) against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus

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Abstract

Staphylococcus aureus and methicillin-resistant S. aureus are major pathogens. The antimicrobial peptides and essential oils (EOs) display narrow- or broad-spectrum activity against bacteria including these strains. A centralized resource, such as a database, designed specifically for anti-S. aureus/anti-methicillin-resistant S. aureus antimicrobial peptides and EOs is therefore needed to facilitate the comprehensive investigation of their structure/activity associations and combinations. The database ANTISTAPHYBASE is created to facilitate access to important information on antimicrobial peptides and essential peptides against methicillin-resistant S. aureus and S. aureus. At the moment, the database contains 596 sequences of antimicrobial peptides produced by diverse organisms and 287 essential oil records. It permits a quick and easy search of peptides based on their activity as well as their general, physicochemical properties and literature data. These data are very useful to perform further bioinformatic or chemometric analysis and would certainly be useful for the development of new drugs for medical use. The ANTISTAPHYBASE database is freely available at: https://www.antistaphybase.com/.

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Acknowledgments

Authors thank Dr. Sadok Mokthar for their critical reading of the manuscript and Mr Samir Borji for his contributions to the database-related work described here. We thank Mme Aziza Cherif  and Mr Houcine Zouheir for their support.

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Authors and Affiliations

  1. Nutraceuticals and Functional Proteomics Potential of Biodiversity in Tunisia, University of Tunis ELMANAR, Tunis, Tunisia

    Abdelmajid Zouhir, Mohamed Ashraf Lamine, Taoufik Jridi, Basma Mahjoubi, Sarra Mbarek, Khaled Sebei & Jeannette Ben Hamida

  2. Research Unit at Institute of Applied Biological Sciences Tunis (ISSBAT), Tunis, Tunisia

    Abdelmajid Zouhir, Mohamed Ashraf Lamine, Taoufik Jridi, Basma Mahjoubi, Sarra Mbarek, Khaled Sebei & Jeannette Ben Hamida

  3. Faculty of Sciences of Gabes, University of gabes, Gabès, Tunisia

    Malek Taieb

  4. Faculty of Sciences of Tunis, Université of El Manar , Tunis, Tunisia

    Ammar Cherif

  5. Institut des Nutraceutiques et des Aliments Fonctionnels (INAF), Université Laval, Quebec, Canada

    Ismail Fliss

  6. Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA

    Adel Nefzi

Authors
  1. Abdelmajid Zouhir
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  2. Malek Taieb
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  3. Mohamed Ashraf Lamine
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  4. Ammar Cherif
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  7. Sarra Mbarek
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  8. Ismail Fliss
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  9. Adel Nefzi
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  10. Khaled Sebei
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  11. Jeannette Ben Hamida
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Corresponding author

Correspondence to Abdelmajid Zouhir.

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Communicated by Erko Stackebrandt.

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Zouhir, A., Taieb, M., Lamine, M.A. et al. ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (EOs) against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus . Arch Microbiol 199, 215–222 (2017). https://doi.org/10.1007/s00203-016-1293-6

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  • DOI: https://doi.org/10.1007/s00203-016-1293-6

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