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Intravesical injection of botulinum toxin A for treatment of interstitial cystitis/bladder pain syndrome: 10 years of experience at a single center in China

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Abstract

Introduction and hypothesis

To evaluate the efficacy and safety of the intravesical injection of Chinese botulinum toxin A (BTX-A) in patients with interstitial cystitis/bladder pain syndrome (IC/BPS).

Methods

Between January 2003 and June 2013, 124 women with IC/BPS were studied. Of these 124 patients, 66 were treated with BTX-A and 58 underwent bladder hydrodistention plus sodium hyaluronate (Cystistat) instillation. Intravesical injection of 100 U of Chinese BTX-A was immediately followed by cystoscopic hydrodistention under intravenous general anesthesia. The patients were evaluated using the O’Leary-Saint score, a visual analog scale pain score, a urinary frequency record and a quality of life questionnaire before treatment and 1 week, and 1, 3, 6 and 12 months after treatment.

Results

Of the patients who received BTX-A injection, only 2 had acute urinary retention, 23 received a repeat injection, and 20 were lost to follow-up. Of the patients treated with hydrodistention plus Cystistat instillation, 2 had urinary tract infection, 11 switched to BTX-A injection at 6 months, and 23 were lost to follow-up. BTX-A was shown to remain effective for up to 6 months after treatment. After repeated Chinese BTX-A injections, symptoms improved significantly. Hydrodistention plus Cystistat remained effective for up to 3 months after treatment.

Conclusions

Intravesical injection of Chinese BTX-A is a safe and effective therapeutic option for patients with IC/BPS. The average duration of the effect of one dose of Chinese BTX-A amongst the responders was 6 months. Repeated injection of Chinese BTX-A is safe and effective.

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Acknowledgments

This study was supported by China National Key Technology R&D Program (no. 2012BAI34B02).

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Urology, China Rehabilitation Research Centre, Department of Urology of Capital Medical University, No. 10 Jiaomen North Road, Fengtai District, Beijing, 100068, China

    Yi Gao & Limin Liao

Authors
  1. Yi Gao
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  2. Limin Liao
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Correspondence to Limin Liao.

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Author participation

Y.G. collected the data, performed the statistical analysis, and drafted the manuscript. L.L. contributed to the conception and design of the study, analysis and interpretation of the data, and helped draft the manuscript. Both authors read and approved the final version of the manuscript.

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Gao, Y., Liao, L. Intravesical injection of botulinum toxin A for treatment of interstitial cystitis/bladder pain syndrome: 10 years of experience at a single center in China. Int Urogynecol J 26, 1021–1026 (2015). https://doi.org/10.1007/s00192-015-2631-y

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  • DOI: https://doi.org/10.1007/s00192-015-2631-y

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