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Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis

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Abstract

Introduction and hypothesis

Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS).

Methods

Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL®, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months.

Results

The score for urgency was reduced from 6.5 to 3.6 (p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p = 0.0001). The average urine volume increased from 129.7 to 162 ml (p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 (p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 (p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 (p < 0.0001).

Conclusion

The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.

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Authors and Affiliations

  1. Urology Department, IRCCS Policlinico San Matteo, Pavia, Italy

    Daniele Porru, Fabio Leva, Alberto Parmigiani, Davide Barletta, Dimitrios Choussos & Bruno Rovereto

  2. Obstetric and Gynecology Clinics, IRCCS Policlinico San Matteo, Pavia, Italy

    Barbara Gardella, Maria Diletta Daccò & Arsenio Spinillo

  3. UO di Medicina Interna and Endocrinologia, IRCCS Fondazione S. Maugeri, Pavia, Italy

    Rossella Elena Nappi

  4. Pain Clinic Section, IRCCS Policlinico San Matteo, Pavia, Italy

    Massimo Allegri

  5. Service of Biometry and Clinical Epidemiology, Scientific Direction–IRCCS Policlinico San Matteo, Pavia, Italy

    Carmine Tinelli

  6. School of Specialization in Urology, University of Pavia, Pavia, Italy

    Carlo Maria Bianchi

  7. Divisione Urologia, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia, 27100, Italy

    Daniele Porru

Authors
  1. Daniele Porru
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  2. Fabio Leva
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  7. Maria Diletta Daccò
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  9. Massimo Allegri
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  10. Carmine Tinelli
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  11. Carlo Maria Bianchi
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  12. Arsenio Spinillo
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  13. Bruno Rovereto
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Correspondence to Daniele Porru.

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Porru, D., Leva, F., Parmigiani, A. et al. Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. Int Urogynecol J 23, 1193–1199 (2012). https://doi.org/10.1007/s00192-011-1546-5

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  • DOI: https://doi.org/10.1007/s00192-011-1546-5

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