Efficiencies for optimum designs when transforming the response in nonlinear models with nonconstant variance

Abstract

Often the responses from mechanistic models have to be transformed to achieve error distributions that are symmetric and have constant variance. Because of the nature of the relationship between the response and the mechanistic model, it is necessary to transform both sides of the model. Expressions are given for the parameter sensitivities in the transformed model and examples given of optimum designs for particular values of λ, together with the efficiency of these designs as λ varies. Approaches to finding designs robust to variations in λ are indicated and exemplified.