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Evaluation of Tetrahydrobiopterin Pathway in Operating Room Workers: Changes in Biopterin Status and Tryptophan Metabolism

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Abstract

The aim of the study was to evaluate the effect of anesthetics as operating room contaminants on tetrahydrobiopterin pathway in 40 operating room personnel and 30 healthy controls by measuring biopterin, dihydrobiopterin reductase, tryptophan, kynurenine and serotonin. Biopterin concentrations were 124 ± 12.3 µmol/mol creatinine in workers and 88 ± 5.7 µmol/mol creatinine in controls whereas kynurenine concentrations were 1.75 ± 0.09 µM and 1.95 ± 0.06 µM, respectively (both, p < 0.05). It can be claimed that enhanced biopterin and diminished kynurenine levels may play a triggering role in disruption of metabolic events in operating room personnel.

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Authors and Affiliations

  1. Clinic of Anesthesiology, Numune Hospital, Ankara, Turkey

    Mustafa Baydar

  2. Clinic of Anesthesiology, Ankara Hospital, Ankara, Turkey

    Zeynep Capan

  3. Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 90-06100, Ankara, Turkey

    Gozde Girgin, S. Sezin Palabiyik, Gonul Sahin & Terken Baydar

  4. Department of Toxicology, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey

    S. Sezin Palabiyik

  5. Department of Toxicology, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, T.R. North Cyprus

    Gonul Sahin

  6. Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria

    Dietmar Fuchs

Authors
  1. Mustafa Baydar
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  2. Zeynep Capan
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  3. Gozde Girgin
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  4. S. Sezin Palabiyik
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  5. Gonul Sahin
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  6. Dietmar Fuchs
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  7. Terken Baydar
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Correspondence to Terken Baydar.

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Baydar, M., Capan, Z., Girgin, G. et al. Evaluation of Tetrahydrobiopterin Pathway in Operating Room Workers: Changes in Biopterin Status and Tryptophan Metabolism. Bull Environ Contam Toxicol 89, 1125–1128 (2012). https://doi.org/10.1007/s00128-012-0845-y

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  • DOI: https://doi.org/10.1007/s00128-012-0845-y

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