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‘The GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on serum insulin release.’
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The online version of the original article can be found at http://dx.doi.org/10.1007/s00125-007-0865-z.
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Sparsø, T., Andersen, G., Nielsen, T. et al. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia 51, 383 (2008). https://doi.org/10.1007/s00125-007-0900-0
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DOI: https://doi.org/10.1007/s00125-007-0900-0