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Pelvine Lymphadenektomie

Komplikationsmanagement

Pelvic lymph node dissection

Complication management

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Zusammenfassung

Die ausgedehnte pelvine Lymphadenektomie liefert exakte Angaben zum Lymphknotenstatus und verbessert darüber hinaus möglicherweise den Krankheitsverlauf. Diesen Vorteilen stehen mögliche peri- und postoperative Komplikationen gegenüber. Bei intraoperativer Läsion des N. obturatorius sollte eine mikrochirurgische epineurale Nervennaht erfolgen. Postoperativ sollte der Patient aufgeklärt, neurologisch vorgestellt und krankengymnastisch behandelt werden.

Die häufigste postoperative Komplikation ist die (symptomatische) Lymphozele. Sie tritt häufiger nach einem extraperitonealen Eingriff auf. Sorgfältige Präparation der Lymphknoten mit Klippung der Lymphbahnen, Aussparen der lateralen Wand der A. iliaca externa bei der Lymphknotendissektion, ausreichend lange postoperative Drainage und Applikation von niedermolekularem Heparin in den Oberarm können das Risiko für eine postoperative Lymphozele reduzieren.

Die Instillation sklerosierender Medikamente und eine längere Drainage führen in der Regel zu einem Sistieren der Lymphsekretion. Ist dies nicht der Fall, kann die laparoskopische Fensterung mit hoher Erfolgsrate die Lymphozele sanieren. Wichtig sind regelmäßige Ultraschallkontrollen im postoperativen Verlauf, um Lymphozelen rechtzeitig zu erkennen und zu behandeln.

Abstract

Extended pelvic lymph node dissection allows exact lymph node staging and has the potential to improve prognosis. In addition to these advantages, there are some perioperative and postoperative complications. In case of transection of the obturator nerve, a microsurgical end-to-end anastomosis should be performed.

The most frequent postoperative complication is (symptomatic) lymphocele which is predominantly diagnosed after extraperitoneal surgery. Meticulous lymph node dissection with clipping of lymphatic vessels, sparing the lateral wall of the external iliac artery from dissection, sufficient postoperative drainage, and application of low molecular weight heparin in the upper arm may reduce their incidence.

Instillation of sclerosing agents and sufficient drainage are normally successful. If not, laparoscopic fenestration of lymphocele should be performed. Regular ultrasound examinations are necessary to diagnose and treat postoperative lymphocele in a timely manner.

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Literatur

  1. Bader P, Burkhard FC, Markwalder R, Studer UE (2002) Is a limited lymph node dissection an adequate staging procedure for prostate cancer? J Urol 168:514–518

    Article  PubMed  Google Scholar 

  2. Bader P, Burkhard FC, Markwalder R, Studer UE (2003) Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? J Urol 169:849–854

    Article  PubMed  Google Scholar 

  3. Briganti A, Karnes JR, Da Pozzo LF et al (2009) Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer. A new proposal based on a two-institution experience on 703 consecutive N+ patients treated with radical prostatectomy, extended pelvic lymph node dissection and adjuvant therapy. Eur Urol 55:261–270

    Article  PubMed  Google Scholar 

  4. Daneshmand S, Quek ML, Stein JP et al (2004) Prognosis of patients with lymph node positive prostate cancer following radical prostatectomy: long-term results. J Urol 172:2252–2255

    Article  PubMed  Google Scholar 

  5. Froehner M, Novotny V, Koch R et al (2013) Perioperative complications after radical prostatectomy: open versus robot-assisted laparoscopic approach. Urol Int 90:312–315

    Article  PubMed  Google Scholar 

  6. Ghaemmaghami F, Behnamfar F, Saberi H (2009) Immediate grafting of transected obturator nerve during radical hysterectomy. Int J Surg 7:168–169

    Article  PubMed  Google Scholar 

  7. Heidenreich A, Varga, Z, Knobloch R von (2002) Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol 167:1681–1686

    Article  PubMed  Google Scholar 

  8. Herr HW, Bochner BH, Dalbagni G et al (2002) Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol 167:1295–1298

    Article  PubMed  Google Scholar 

  9. Holl G, Dorn R, Wengenmair H et al (2009) Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2000 patients. Eur J Nucl Med Mol Imaging 36:1377–1382

    Article  CAS  PubMed  Google Scholar 

  10. Ji J, Yuan H, Wang L, Hou J (2012) Is the impact of the extent of lymphadenectomy in radical prostatectomy related to the disease risk? A single center prospective study. J Surg Res 178:779–784

    Article  PubMed  Google Scholar 

  11. Khoder WY, Trottmann M, Buchner A et al (2011) Risk factors for pelvic lymphoceles post-radical prostatectomy. Int J Urol 18:638–643

    PubMed  Google Scholar 

  12. Khoder WY, Gratzke C, Haseke N et al (2012) Laparoscopic marsupialisation of pelvic lymphoceles in different anatomic locations following radical prostatectomy. Eur Urol 62:640–648

    Article  PubMed  Google Scholar 

  13. Leissner J, Hohenfellner R, Thüroff JW, Wolf HK (2000) Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int 85:817–823

    Article  CAS  PubMed  Google Scholar 

  14. Liss MA, Palazzi K, Stroup SP et al (2013) Outcomes and complications of pelvic lymph node dissection during robotic-assisted radical prostatectomy. World J Urol 31:481–488

    Article  PubMed  Google Scholar 

  15. Mundhenk J, Hennenlotter J, Alloussi S et al (2013) Influence of body mass index, surgical approach and lymphadenectomy on the development of symptomatic lymhoceles after radical prostatectomy. Urol Int 90:270–276

    Article  CAS  PubMed  Google Scholar 

  16. Nezhat FR, Chang-Jackson SC, Acholonu UC Jr, Vetere PF (2012) Robotic-assisted laparoscopic transection and repair of an obturator nerve during pelvic lymphadenectomy for endometrial cancer. Obstet Gynecol 119:462–464

    Article  PubMed  Google Scholar 

  17. Ploussard G, Briganti A, Taille A de la et al (2014) Pelvic lymph node dissection during robot-assisted radical prostatectomy: efficacy, limitations, and complications – a systematic review of the literature. Eur Urol 65:7–16

    Article  PubMed  Google Scholar 

  18. Rousseau B, Doucet L, Perrouin Verbe MA et al (2014) Comparison of the morbidity between limided and extended pelvic lymphadenectomy during laparoscopic radical prostatectomy. Prog Urol 24:114–120

    Article  CAS  PubMed  Google Scholar 

  19. Sagalovich D, Calaway A, Srivastava A et al (2013) Assessment of required nodal yield in a high risk cohort undergoing extended pelvic lymphadenectomy in robotic-assisted radical prostatectomy and its impact on functional outcomes. BJU Int 111:85–94

    Article  PubMed  Google Scholar 

  20. Schumacher MC, Burkhard FC, Thalmann GN et al (2008) Good outcome for patients with few lymph node metastases after radical retropubic prostatectomy. Eur Urol 54:344–352

    Article  PubMed  Google Scholar 

  21. Spaliviero M, Steinberg AP, Kaouk JH et al (2004) Laparoscopic injury and repair of obturator nerve during radical prostatectomy. Urology 64:1030

    Article  PubMed  Google Scholar 

  22. Stolzenburg JU, Wasserscheid J, Rabenalt R et al (2008) Reduction in incidence of lymphocele following extraperitoneal radical prostatectomy and pelvic lymph node dissection by bilateral peritoneal fenestration. World J Urol 26:581–586

    Article  PubMed  Google Scholar 

  23. Treiyer A, Stark E, Ting O et al (2009) Laparoscopic lymphocelectomy. BJU Int 103:1588–1597

    Article  PubMed  Google Scholar 

  24. Wawroschek F, Vogt H, Weckermann D et al (1999) The sentinel lymph node concept in prostate cancer – first results of gamma probe-guided sentinel lymph node identification. Eur Urol 36:595–600

    Article  CAS  PubMed  Google Scholar 

  25. Weckermann D, Dorn R, Trefz M et al (2007) Sentinel lymph node dissection for prostate cancer: experience with more than 1000 patients. J Urol 177:916–920

    Article  PubMed  Google Scholar 

  26. Woods ME, Ouwenga M, Quek ML (2007) The role of pelvic lymphadenectomy in the management of prostate and bladder cancer. Scientific World J 7:789–799

    Article  Google Scholar 

  27. Yasumizu Y, Miyajima A, Maeda T et al (2013) How can lymphocele development be prevented after laparoscopic radical prostatectomy? J Endourol 27:447–451

    Article  PubMed  Google Scholar 

  28. Zwergel U, Lehmann J, Wullich B et al (2004) Lymph node positive prostate cancer: long-term survival data after radical prostatectomy. J Urol 171:1128–1131

    Article  PubMed  Google Scholar 

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Einhaltung ethischer Richtlinien

Interessenkonflikt. D. Weckermann gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Weckermann, D. Pelvine Lymphadenektomie. Urologe 53, 996–1000 (2014). https://doi.org/10.1007/s00120-014-3480-x

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