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Pharmaka zur Verbesserung motorischer Defizite nach einem Schlaganfall

Drugs for improvement of motor deficits after stroke

  • Leitthema
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Zusammenfassung

Seit ca. 20 Jahren werden kontrollierte randomisierte Studien mit unterschiedlichen Medikamenten durchgeführt, um die motorische Funktionsrestitution nach einem Schlaganfall zu unterstützen. Bislang zeigen Serotoninwiederaufnahmehemmer mit der größten Anzahl positiv verlaufener Studien die deutlichste Evidenz einer Wirksamkeit. Auch für L‑Dopa ergeben sich Hinweise für eine funktionsfördernde Wirkung bei allerdings erheblich weniger Studien. Für Amphetamine besteht eine überwiegend negative Datenlage. Auch D‑Cycloserin kann nicht empfohlen werden. Zukünftige therapeutische Ansätze wie Anti-Nogo-Antikörper und Zelltherapie werden dargestellt.

Abstract

Randomized controlled trials with a variety of drugs have been performed for approximately 20 years in order to support functional restitution of motor deficits after a stroke. Nowadays, serotonin reuptake inhibitors show the highest level of evidence due to the largest number of positive studies and L‑dopa also seems to be effective; however, much fewer studies have been conducted. In the majority of trials amphetamines provided no additional benefits and D‑cycloserine cannot be recommended either. Future therapeutic approaches, e.g. anti-nogo antibodies and cell therapy are presented.

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Authors and Affiliations

  1. Kliniken Schmieder Allensbach, Zum Tafelholz 8, 78476, Allensbach, Deutschland

    J. Liepert

  2. Lurija Institut für Rehabilitationswissenschaften und Gesundheitsforschung, Allensbach, Deutschland

    J. Liepert

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Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

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Liepert, J. Pharmaka zur Verbesserung motorischer Defizite nach einem Schlaganfall. Nervenarzt 87, 1082–1085 (2016). https://doi.org/10.1007/s00115-016-0216-8

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  • DOI: https://doi.org/10.1007/s00115-016-0216-8

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