Zusammenfassung
Der Begriff Spondyloarthritiden (SpA) umfasst eine Gruppe von rheumatischen Erkrankungen, die neben einer Entzündung des Achsenskeletts (Sakroiliitis, Spondylitis) auch durch eine Entzündung peripherer Gelenke (Arthritis) und Sehnenansätze (Enthesitis) charakterisiert ist. Das Management der Erkrankung orientiert sich an der aktuellen Krankheitsmanifestation, der Krankheitsaktivität und der Einschränkung der Funktionsfähigkeit. Im vorliegenden Übersichtsbeitrag wird auf die Diagnose und Therapie der axialen SpA eingegangen. Die diagnostischen Prozeduren werden insbesondere vor dem Hintergrund der diagnostischen Wertigkeit und Praktikabilität in der klinischen Routine vorgestellt. Die Darstellung therapeutischer Optionen umfasst Bewegungsübungen wie auch medikamentöse Therapiemaßnahmen und invasive Prozeduren.
Abstract
The term spondyloarthritis (SpA) is now increasingly used to classify and diagnose patients who are characterized by inflammation in the axial skeleton and peripheral manifestations (arthritis and enthesitis). The management of SpA should be tailored according to the current manifestations of the disease, the disease activity and functional impairment. The current article focuses on diagnosis and therapy in patients with axial SpA. Diagnostic procedures are discussed in light of diagnostic utility and feasibility in daily routine care. Cornerstones of treatment in patients with axial SpA are a combination of regular exercise and pharmacological treatment options aiming at anti-inflammatory strategies.
Literatur
Dougados M, Baeten D (2011) Spondyloarthritis. Lancet 377(9783):2127–2137
Rudwaleit M et al (2009) The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): Validation and final selection. Ann Rheum Dis 68(6):777–783
Rudwaleit M et al (2011) The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70(1):25–31
Smith JA, Colbert RA (2014) The IL-23/IL-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheum 66:231–241
Neidhart M et al (2009) Expression of cathepsin K and matrix metalloproteinase 1 indicate persistent osteodestructive activity in long-standing ankylosing spondylitis. Ann Rheum Dis 68(8):1334–1339
Van der Heijde D et al (2016) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 75(Suppl 2):44
Kiltz U, Braun J (2014) German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew’s disease and early forms: Editorial. Z Rheumatol 73(Suppl 2):20–22
Rudwaleit M et al (2006) Inflammatory back pain in ankylosing spondylitis: A reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum 54(2):569–578
Essers I et al (2015) Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS. Rheumatology (Oxford) 54(4):633–640
Feldtkeller E et al (2003) Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 23(2):61–66
Ramiro S et al (2015) Reference intervals of spinal mobility measures in normal individuals: the MOBILITY study. Ann Rheum Dis 74(6):1218–1224
Sieper J et al (2009) The Assessment of SpondyloArthritis international Society (ASAS) handbook: A guide to assess spondyloarthritis. Ann Rheum Dis 68(Suppl 2):ii1–ii44
Poddubnyy D et al (2012) Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum 64(5):1388–1398
Braun J et al (1998) Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41(1):58–67
Kiltz U et al (2014) German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew’s disease and early forms: 8.3 Nonpharmaceutical therapeutic measures. Z Rheumatol 73(Suppl 2):71–77
Kiltz U et al (2014) German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew’s disease and early forms: 8.4 Pharmaceutical therapy, 8.5 Evaluation of therapy success of pharmaceutical measures. Z Rheumatol 73(Suppl 2):78–96
Rudwaleit M et al (2009) The early disease stage in axial spondylarthritis: Results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum 60(3):717–727
Poddubnyy D et al (2012) Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: Results from the German Spondyloarthritis Inception Cohort. Ann Rheum Dis 71(10):1616–1622
Maxwell LJ et al (2015) TNF-alpha inhibitors for ankylosing spondylitis. Cochrane Database Syst Rev 4:CD005468
Baraliakos X et al (2013) Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis. Ann Rheum Dis 73(4):710–715. doi:10.1136/annrheumdis-2012-202698
Navarro-Compan V et al (2016) Anti-TNF discontinuation and tapering strategies in patients with axial spondyloarthritis: A systematic literature review. Rheumatology (Oxford) 55(7):1188–1194. doi:10.1093/rheumatology/kew033
Baeten D et al (2015) Secukinumab, an Interleukin-17A inhibitor, in Ankylosing Spondylitis. N Engl J Med 373(26):2534–2548
Kiltz U et al (2014) German Society for Rheumatology S3 guidelines on axial spondyloarthritis including Bechterew’s disease and early forms: 8.6 Invasive therapy. Z Rheumatol 73(Suppl 2):97–100
Heuft-Dorenbosch L et al (2007) Performance of various criteria sets in patients with inflammatory back pain of short duration; The Maastricht early spondyloarthritis clinic. Ann Rheum Dis 66(1):92–98
Wanders A et al (2005) Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: A randomized clinical trial. Arthritis Rheum 52(6):1756–1765
Sieper J et al (2015) Effect of continuous versus on-demand treatment of ankylosing spondylitis with diclofenac over 2 years on radiographic progression of the spine: Results from a randomised multicentre trial (ENRADAS). Ann Rheum Dis 75(8):1438–1443. doi:10.1136/annrheumdis-2015-207897
van der Heijde D et al (2008) Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum 58(5):1324–1331
Rudwaleit M et al (2005) The challenge of diagnosis and classification in early ankylosing spondylitis. Do we need new criteria? Arthritis Rheum 52(4):1000–1008
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
U. Kiltz, X. Baraliakos und J. Braun geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Additional information
Redaktion
E. Märker-Hermann, Wiesbaden
Rights and permissions
About this article
Cite this article
Kiltz, U., Baraliakos, X. & Braun, J. Management der axialen Spondyloarthritis. Internist 57, 1060–1068 (2016). https://doi.org/10.1007/s00108-016-0140-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00108-016-0140-9