Skip to main content
SpringerLink
Log in

HIV‑assoziiertes plasmoblastisches Lymphom der Nasennebenhöhlen

Ein Zufallsbefund

HIV-associated plasmablastic lymphoma of the paranasal sinuses

An incidental finding

  • Kasuistiken
  • Published:
HNO Aims and scope Submit manuscript

Zusammenfassung

Es wird der Fall einer 48-jährigen Patientin beschrieben, die sich mit einer einseitigen Nasenatmungsbehinderung, linksbetonten Zephalgien und subfebrilen Temperaturen in der HNO-Klinik der Universitätsmedizin Mainz vorstellte. Die klinische Untersuchung und die CT der Nasennebenhöhlen zeigte eine Raumforderung der linken Nasenhaupthöhle und des linken Nasennebenhöhlensystems. Die histopathologische Aufarbeitung ergab ein HIV-assoziiertes plasmoblastisches Lymphom der Nasennebenhöhlen. Diese Kasuistik mit Übersicht über die Literatur stellt die Diagnostik und Therapie dieses seltenen Nasentumors dar.

Abstract

A 48-year-old female patient presented to the ENT department of the University Medical Center of the Johannes Gutenberg University Mainz with subfebrile temperatures, one-sided nasal obstruction, and left-sided cephalgia. Clinical examination and CT scans showed a mass occupying the left nasal cavity and left paranasal sinuses. Further diagnosis and histopathological examination showed an HIV-associated plasmablastic lymphoma of the left paranasal sinuses. This case report with literature review discusses the diagnosis and treatment of this rare nasal tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1a,b
Abb. 2a,b
Abb. 3
Abb. 4

Literatur

  1. Bibas M, Castillo JJ (2014) Current knowledge on HIV-associated plasmablastic lymphoma. Mediterr J Hematol Infect Dis 6:e2014064

    Article  PubMed  PubMed Central  Google Scholar 

  2. Castillo JJ, Bibas M, Miranda RN (2015) The biology and treatment of plasmablastic lymphoma. Blood 125:2323–2330

    Article  CAS  PubMed  Google Scholar 

  3. Castillo JJ, Furman M, Beltran BE et al (2012) Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy. Cancer 118:5270–5277

    Article  PubMed  Google Scholar 

  4. Colomo L, Loong F, Rives S et al (2004) Diffuse large B‑cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol 28:736–747

    Article  PubMed  Google Scholar 

  5. Delecluse HJ, Anagnostopoulos I, Dallenbach F et al (1997) Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 89:1413–1420

    CAS  PubMed  Google Scholar 

  6. Laurent C, Fabiani B, Do C et al (2016) Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients. Haematologica 101:976–984

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Loghavi S, Alayed K, Aladily TN et al (2015) Stage, age, and EBV status impact outcomes of plasmablastic lymphoma patients: a clinicopathologic analysis of 61 patients. J Hematol Oncol 8:65

    Article  PubMed  PubMed Central  Google Scholar 

  8. Morscio J, Dierickx D, Nijs J et al (2014) Clinicopathologic comparison of plasmablastic lymphoma in HIV-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases. Am J Surg Pathol 38:875–886

    Article  PubMed  Google Scholar 

  9. Nasta SD, Carrum GM, Shahab I et al (2002) Regression of a plasmablastic lymphoma in a patient with HIV on highly active antiretroviral therapy. Leuk Lymphoma 43:423–426

    Article  PubMed  Google Scholar 

  10. Shiboski CH, Webster-Cyriaque JY, Ghannoum M et al (2011) Overview of the oral HIV/AIDS Research Alliance Program. Adv Dent Res 23:28–33

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Zelenetz AD (2014) Guidelines for NHL: updates to the management of diffuse large B‑cell lymphoma and new guidelines for primary cutaneous CD30+ T‑cell lymphoproliferative disorders and T‑cell large granular lymphocytic leukemia. J Natl Compr Canc Netw 12:797–800

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Hals-Nasen-Ohrenheilkunde, Unimedizin Mainz, Langenbeckstr. 1, 55101, Mainz, Deutschland

    V. Weber, K. Helling & C. Matthias

Authors
  1. V. Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Helling
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Matthias
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. Weber.

Ethics declarations

Interessenkonflikt

V. Weber, K. Helling und C. Matthias geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.

Additional information

Redaktion

C. Matthias, Mainz

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weber, V., Helling, K. & Matthias, C. HIV‑assoziiertes plasmoblastisches Lymphom der Nasennebenhöhlen. HNO 66, 144–147 (2018). https://doi.org/10.1007/s00106-017-0373-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00106-017-0373-5

Schlüsselwörter

Keywords

Search

Navigation