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Photosensibilisierung durch Methotrexat

Methotrexate-associated photosensitization

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Zusammenfassung

Hintergrund

Methotrexat (MTX) ist in Deutschland neben Fumarsäure-Estern das am häufigsten für die Behandlung der Psoriasis eingesetzte Systemtherapeutikum. Aufgrund synergistischer Effekte erfolgt gelegentlich eine Kombination von MTX mit Lokal- und/oder Phototherapie.

Fallbericht

Wir beschreiben hier den Fall einer protrahierten phototoxischen Dermatitis unter MTX. Neben der akuten Phototoxizität kann es durch MTX zu einer sog. UV-Reaktivierung, einer Reaktivierung einer Radiodermatitis und der Entstehung von Hauttumoren kommen.

Abstract

Background

Methotrexate (MTX), alongside fumaric acid esters, is the most commonly used drug in the systemic therapy of psoriasis in Germany. It is sometimes used in combination with topical therapy and/or phototherapy due to synergistic effects.

Case report

Here we describe a case of phototoxic dermatitis during treatment with MTX. Other cutaneous side effects of MTX include so-called UV recall, radiation recall, and skin tumor formation.

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Authors and Affiliations

  1. Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstraße 7, 79104, Freiburg, Deutschland

    K. Hoffmann, F. Casetti & C. Schempp

Authors
  1. K. Hoffmann
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  2. F. Casetti
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  3. C. Schempp
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Corresponding author

Correspondence to K. Hoffmann.

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Interessenkonflikt

K. Hoffmann, F. Casetti und C. Schempp geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Hoffmann, K., Casetti, F. & Schempp, C. Photosensibilisierung durch Methotrexat. Hautarzt 66, 459–461 (2015). https://doi.org/10.1007/s00105-014-3569-6

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  • DOI: https://doi.org/10.1007/s00105-014-3569-6

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