Zusammenfassung
Die chirurgische Therapie von Lungenmetastasen extrathorakaler Malignome ist etabliert. Eine pulmonale Metastasierung ist häufig. In der Regel sind Lungenmetastasen peripher gelegen und asymptomatisch. Durch Tumoreinbruch in das Bronchialsystem oder die Brustwand kann es zu Beschwerden kommen. Die Indikation zur Resektion wird interdisziplinär gestellt. Sie kann in kurativer und palliativer Intention erfolgen. Voraussetzung hierfür ist, dass der Primärtumor kontrolliert ist, dass extrathorakale Metastasen sowie alternative Erfolg versprechende Therapieformen fehlen und alle Metastasen komplett, mit vertretbarem allgemeinem und funktionellem Risiko, resezierbar sind. Es dominieren extraanatomische Resektionen. Die perioperative Morbidität und Mortalität ist niedrig. Es besteht bei einem selektionierten Patientenkollektiv die Möglichkeit der Kuration.
Abstract
Surgical treatment of lung metastases from extrathoracic malignancies is an established procedure. Pulmonary metastases are common. Generally, lung metastases are located peripherally and are asymptomatic. Involvement of the bronchial system or infiltration of the chest wall can be symptomatic. The indications for resection are an interdisciplinary decision. Metastasectomy can be with curative or palliative intent. Prerequisitess for pulmonary metastasectomy are primary tumor under control, the absence of extrathoracic metastases, the lack of other promising treatment options, the possibility for complete resection and low perioperative risk. Extra-anatomic resections are common. Perioperative morbidity and mortality is low. A cure is possible in selected patients.
Literatur
Fisseler-Eckhoff A, Muller KM (2000) Differential diagnosis of primary lung tumors and pulmonary metastases. Verh Dtsch Ges Pathol 84:106–117
Sorensen JB (2004) Endobronchial metastases from extrapulmonary solid tumors. Acta Oncol 43(1):73–79
Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49:357–363
Vogt-Moykopf I, Krysa S, Bulzebruck H, Schirren J (1994) Surgery for pulmonary metastases. The Heidelberg experience. Chest Surg Clin N Am 4(1):85–112
Detterbeck FC, Grodzki T, Gleeson F, Robert JH (2010) Imaging requirements in the practice of pulmonary metastasectomy. J Thorac Oncol 5(6 Suppl 2):S134–S139
Schirren J, Trainer S, Schneider P et al (1994) Are video-assisted thoracoscopic resections in oncological surgery defensible? Chirurg 65(8):664–670
Branscheid D, Krysa S, Wollkopf G et al (1992) Does ND-YAG laser extend the indications for resection of pulmonary metastases? Eur J Cardiothorac Surg 6(11):590–596 (discussion 597)
Spaggiari L, Grunenwald DH, Girard P et al (1998) Pneumonectomy for lung metastases: indications, risks, and outcome. Ann Thorac Surg 66(6):1930–1933
Pfannschmidt J, Muley T, Hoffmann H, Dienemann H (2003) Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 126(3):732–739
Bolukbas S, Sponholz S, Kudelin N et al (2014) Risk factors for lymph node metastases and prognosticators of survival in patients undergoing pulmonary metastasectomy for colorectal cancer. Ann Thorac Surg 97(6):1926–1932
Kudelin N, Bolukbas S, Eberlein M, Schirren J (2013) Metastasectomy with standardized lymph node dissection for metastatic renal cell carcinoma: an 11-year single-center experience. Ann Thorac Surg 96(1):265–270 (discussion 270–271)
Pfannschmidt J, Hoffmann H, Dienemann H (2010) Reported outcome factors for pulmonary resection in metastatic colorectal cancer. J Thorac Oncol 5(6 Suppl 2):S172–S178
Rodriguez-Fuster A, Belda-Sanchis J, Aguilo R et al (2014) Morbidity and mortality in a large series of surgical patients with pulmonary metastases of colorectal carcinoma: a prospective multicentre Spanish study (GECMP-CCR-SEPAR). Eur J Cardiothorac Surg 45(4):671–676
Schirren J, Trainer S, Eberlein M et al (2012) The role of residual tumor resection in the management of nonseminomatous germ cell cancer of testicular origin. Thorac Cardiovasc Surg 60(6):405–412
Tuddenham WJ (1984) Glossary of terms for thoracic radiology: recommendations of the Nomenclature Committee of the Fleischner Society. AJR Am J Roentgenol 143(3):509–517
Toomes H, Delphendahl A, Manke HG, Vogt-Moykopf I (1983) The coin lesion of the lung. A review of 955 resected coin lesions. Cancer 51(3):534–537
Quint LE, Park CH, Iannettoni MD (2000) Solitary pulmonary nodules in patients with extrapulmonary neoplasms. Radiology 217(1):257–261
Drings P, Vogt Moykopf I (1998) Thoraxtumoren. Springer, Berlin Heidelberg New York Tokio
Internullo E, Cassivi SD, Van Raemdonck D et al (2008) Pulmonary metastasectomy: a survey of current practice amongst members of the European Society of Thoracic Surgeons. J Thorac Oncol 3(11):1257–1266
Bielack SS, Kempf-Bielack B, Delling G et al (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20(3):776–790
Huang YM, Hou CH, Hou SM, Yang RS (2009) The metastasectomy and timing of pulmonary metastases on the outcome of osteosarcoma patients. Clin Med Oncol 3:99–105
Kager L, Zoubek A, Potschger U et al (2003) Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol 21(10):2011–2018
Rick O, Bokemeyer C, Weinknecht S et al (2004) Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. J Clin Oncol 22(18):3713–3719
Alt AL, Boorjian SA, Lohse CM et al (2011) Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer 117(13):2873–2882
Bolukbas S, Kudelin N, Eberlein M et al (2012) The influence of the primary tumor on the long-term results of pulmonary metastasectomy for metastatic renal cell carcinoma. The Thorac Cardiovasc Surg 60(6):390–397
Ljungberg B, Cowan NC, Hanbury DC et al (2010) EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 58(3):398–406
Pfannschmidt J, Hoffmann H, Muley T et al (2002) Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma. Ann Thorac Surg 74(5):1653–1657
Meimarakis G, Angele M, Staehler M et al (2011) Evaluation of a new prognostic score (Munich score) to predict long-term survival after resection of pulmonary renal cell carcinoma metastases. Am J Surg 202(2):158–167
Labianca R, Beretta GD, Kildani B et al (2010) Colon cancer. Crit Rev Oncol Hematol 74(2):106–133
The International Registry of Lung Metastases – Wiritng Committee (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113(1):37–49
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Interessenkonflikt. M. Schirren, S. Bölükbas, S. Oguzhan, S. Sponholz und J. Schirren geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Schirren, M., Bölükbas, S., Oguzhan, S. et al. Chirurgische Therapie von Lungenmetastasen. Chirurg 85, 833–844 (2014). https://doi.org/10.1007/s00104-013-2685-7
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DOI: https://doi.org/10.1007/s00104-013-2685-7