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Acute and Prophylactic Endovascular Treatment of Internal Carotid Artery Stenosis*

Akute und prophylaktische Behandlung von A.-carotis-interna-Stenosen

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Abstract

Stroke is the third most common cause of death in the USA. Up to 20% of all strokes are caused by internal carotid artery (ICA) stenosis. This article reviews the treatment of ICA stenosis, its indication, and its relevance for stroke prevention. The article also discusses the indication of ICA stenosis treatment in an acute stroke situation and offers pathophysiological commentary.

Zusammenfassung

Der Schlaganfall ist die dritthäufigste Todesursache in den USA. Stenosen der A. carotis interna (ACI) sind Ursache für 20% aller Schlaganfälle. Dieser Artikel gibt einen Überblick über die Indikationsstellung und die schlaganfallpräventive Bedeutung der Behandlung von Stenosen der ACI. Außerdem beschreibt der Artikel die Indikationsstellung und eine pathophysiologische Erläuterung zur Behandlung von ACI-Stenosen beim akuten Schlaganfall.

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References

  1. Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A, Gebel J, Mills D, Minneci L, Shukla R. The Greater Cincinnati/Northern Kentucky Stroke Study: preliminary first-ever and total incidence rates of stroke among blacks. Stroke 1998;29:415–21.

    PubMed  CAS  Google Scholar 

  2. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O’Donnell C, Kittner S, Lloyd-Jones D, Goff DC Jr, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M Wolf P. Heart disease and stroke statistics – 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006;113:e85–151.

    Article  PubMed  Google Scholar 

  3. Lisabeth LD, Ireland JK, Risser JM, Brown DL, Smith MA, Garcia NM, Morgenstern LB. Stroke risk after transient ischemic attack in a population-based setting. Stroke 2004;35:1842–6.

    Article  PubMed  Google Scholar 

  4. Hill MD, Yiannakoulias N, Jeerakathil T, Tu JV, Svenson LW, Schopflocher DP. The high risk of stroke immediately after transient ischemic attack: a population-based study. Neurology 2004;62:2015–20.

    PubMed  CAS  Google Scholar 

  5. Kleindorfer D, Panagos P, Pancioli A, Khoury J, Kissela B, Woo D, Schneider A, Alwell K, Jauch E, Miller R, Moomaw C, Shukla R, Broderick JP. Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke 2005;36:720–3.

    Article  PubMed  Google Scholar 

  6. Johnston SC, Fayad PB, Gorelick PB, Hanley DF, Shwayder P, van Husen D, Weiskopf T. Prevalence and knowledge of transient ischemic attack among US adults. Neurology 2003;60:1429–34.

    PubMed  CAS  Google Scholar 

  7. Coull AJ, Lovett JK, Rothwell PM. Population-based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ 2004;328:326.

    Article  PubMed  CAS  Google Scholar 

  8. Hacke W, Donnan G, Fieschi C, Kaste M, Kummer R von, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004;363:768–74.

    Article  PubMed  Google Scholar 

  9. Kucinski T, Fiehler J. MRT beim akuten Schlaganfall. Clin Neuroradiol 2004;14:56–63.

    Article  Google Scholar 

  10. Eckert B, Koch C, Thomalla G, Kucinski T, Grzyska U, Roether J, Alfke K, Jansen O, Zeumer H. Aggressive therapy with intravenous abciximab and intra-arterial rtPA and additional PTA/stenting improves clinical outcome in acute vertebrobasilar occlusion: combined local fibrinolysis and intravenous abciximab in acute vertebrobasilar stroke treatment (FAST): results of a multicenter study. Stroke 2005;36:1160–5.

    Article  PubMed  CAS  Google Scholar 

  11. Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, Branca V, Sit SP. The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol 2008;29:1409–13.

    Article  PubMed  CAS  Google Scholar 

  12. Pfefferkorn T, Mayer TE, Opherk C, Peters N, Straube A, Pfister HW, Holtmannspotter M, Muller-Schunk S, Wiesmann M, Dichgans M. Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients. Stroke 2008;39:1496–500.

    Article  PubMed  Google Scholar 

  13. Smith P, Arnesen H, Holme I. The effect of warfarin on mortality and reinfarction after myocardial infarction. N Engl J Med 1990;323:147–52.

    PubMed  CAS  Google Scholar 

  14. Van Bergen PFMM, Jonker JC, van der Meer FM, Azar AJ, Meeter K, Deckers JW, Colly LP, Tijssen JGP. Effect of long-term oral anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction. Anticoagulants in the Secondary Prevention of Events in Coronary Thrombosis (ASPECT) Research Group. Lancet 1994;343:499–503.

    Google Scholar 

  15. Tunick PA, Kronzon I. Protruding atheromas in the thoracic aorta: a newly recognized source of cerebral and systemic embolization. Echocardiography 1993;10:419–28.

    Article  PubMed  CAS  Google Scholar 

  16. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329–39.

    Google Scholar 

  17. Albers GW. Antithrombotic agents in cerebral ischemia. Am J Cardiol 1995;75:34B–38B.

    Article  PubMed  CAS  Google Scholar 

  18. Sacco RL, Ellenberg JH, Mohr JP, Tatemichi TK, Hier DB, Price TR, Wolf PA. Infarcts of undetermined cause: the NINCDS Stroke Data Bank. Ann Neurol 1989;25:382–90.

    Article  PubMed  CAS  Google Scholar 

  19. Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Ferguson GG, Haynes RB, Rankin RN, Clagett GP, Hachinski VC, Sackett DL, Thorpe KE, Meldrum HE. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1998;339:1415–25.

    Article  PubMed  CAS  Google Scholar 

  20. Farrell B, Fraser A, Sandercock P, Slattery J, Warlow CP. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998;351:1379–87.

    Article  Google Scholar 

  21. European Carotid Surgery Trialists’ Collaborative Group. Group C, MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis. Lancet 1991;337:1235–43.

  22. Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, Taylor DW, Haynes RB, Finan JW, Hachinski VC, Barnett HJ. The North American Symptomatic Carotid Endarterectomy Trial: surgical results in 1415 patients. Stroke 1999;30:1751–8.

    PubMed  CAS  Google Scholar 

  23. Rothwell PM, Warlow CP. Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists’ Collaborative Group. Lancet 1999;353:2105–10.

    Article  PubMed  CAS  Google Scholar 

  24. Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004;363:915–24.

    Article  PubMed  CAS  Google Scholar 

  25. O’Leary DH, Polak JF, Kronmal RA, Kittner SJ, Bond MG, Wolfson SK Jr, Bommer W, Price TR, Gardin JM, Savage PJ. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke 1992;23:1752–60.

    PubMed  Google Scholar 

  26. Fine-Edelstein JS, Wolf PA, O’Leary DH, Poehlman H, Belanger AJ, Kase CS, D’Agostino RB. Precursors of extracranial carotid atherosclerosis in the Framingham Study. Neurology 1994;44:1046–50.

    PubMed  CAS  Google Scholar 

  27. Hillen T, Nieczaj R, Munzberg H, Schaub R, Borchelt M, Steinhagen-Thiessen E. Carotid atherosclerosis, vascular risk profile and mortality in a population-based sample of functionally healthy elderly subjects: the Berlin ageing study. J Intern Med 2000;247:679–88.

    Article  PubMed  CAS  Google Scholar 

  28. Nadareishvili ZG, Rothwell PM, Beletsky V, Pagniello A, Norris JW. Long-term risk of stroke and other vascular events in patients with asymptomatic carotid artery stenosis. Arch Neurol 2002;59:1162–6.

    Article  PubMed  Google Scholar 

  29. Mackey AE, Abrahamowicz M, Langlois Y, Battista R, Simard D, Bourque F, Leclerc J, Cote R. Outcome of asymptomatic patients with carotid disease. Asymptomatic Cervical Bruit Study Group. Neurology 1997;48:896–903.

    PubMed  CAS  Google Scholar 

  30. Hennerici M, Hulsbomer HB, Hefter H, Lammerts D, Rautenberg W. Natural history of asymptomatic extracranial arterial disease. Results of a long-term prospective study. Brain 1987;110:777–91.

    Article  PubMed  Google Scholar 

  31. Chambers BR, Norris JW. Outcome in patients with asymptomatic neck bruits. N Engl J Med 1986;315:860–5.

    PubMed  CAS  Google Scholar 

  32. Bogousslavsky J, Despland PA, Regli F. Asymptomatic tight stenosis of the internal carotid artery: long-term prognosis. Neurology 1986;36:861–3.

    PubMed  CAS  Google Scholar 

  33. Meissner I, Wiebers DO, Whisnant JP, O’Fallon WM. The natural history of asymptomatic carotid artery occlusive lesions. JAMA 1987;258:2704–7.

    Article  PubMed  CAS  Google Scholar 

  34. Autret A, Pourcelot L, Saudeau D, Marchal C, Bertrand P, de Boisvilliers S. Stroke risk in patients with carotid stenosis. Lancet 1987;1:888–90.

    Article  PubMed  CAS  Google Scholar 

  35. Inzitari D, Eliasziw M, Gates P, Sharpe BL, Chan RK, Meldrum HE, Barnett HJ. The causes and risk of stroke in patients with asymptomatic internalcarotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 2000;342:1693–700.

    Article  PubMed  CAS  Google Scholar 

  36. Barnett HJ, Gunton RW, Eliasziw M, Fleming L, Sharpe B, Gates P, Meldrum H. Causes and severity of ischemic stroke in patients with internal carotid artery stenosis. JAMA 2000;283:1429–36.

    Article  PubMed  CAS  Google Scholar 

  37. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis. JAMA 1995;273:1421–8.

  38. Halliday A, Mansfield A, Marro J, Peto C, Peto R, Potter J, Thomas D. Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 2004;363:1491–502.

    Article  PubMed  CAS  Google Scholar 

  39. Wiggli U, Gratzl O. Transluminal angioplasty of stenotic carotid arteries: case reports and protocol. AJNR Am J Neuroradiol 1983;4:793–5.

    PubMed  CAS  Google Scholar 

  40. Bockenheimer SA, Mathias K. Percutaneous transluminal angioplasty in arteriosclerotic internal carotid artery stenosis. AJNR Am J Neuroradiol 1983;4:791–2.

    PubMed  CAS  Google Scholar 

  41. Munari LM, Belloni G, Perretti A, Ghia HF, Moschini L, Porta M. Carotid percutaneous angioplasty. Neurol Res 1992;14:Suppl 2:S156–8.

    Google Scholar 

  42. Kachel R. Percutaneous transluminal angioplasty of the carotid artery. Wien Klin Wochenschr 1993;105:187–93.

    PubMed  CAS  Google Scholar 

  43. Brown MM. Balloon angioplasty for cerebrovascular disease. Neurol Res 1992;14:Suppl 2:159–63.

    PubMed  CAS  Google Scholar 

  44. Freitag G, Freitag J, Koch RD. Percutaneous transluminal angioplasty of carotid stenoses. Rofo 1984;140:209–12.

    PubMed  CAS  Google Scholar 

  45. Eckert B, Zanella F, Thie A, Steinmetz J, Zeumer H. Angioplatie of the internal carotid artery: result, complications and follow-up in 61 cases. Cerebrovasc Dis 1996;6:97–105.

    Article  Google Scholar 

  46. Koch C, Eckert B, Grzyska U, Zeumer H. Die stentgeschützte perkutane Karotisangioplastie. Klin Neuroradiol 1999;9:30–44.

    Article  Google Scholar 

  47. Teitelbaum GP, Lefkowitz MA, Giannotta SL. Carotid angioplasty and stenting in high-risk patients. Surg Neurol 1998;50:300–11, discussion 311–2.

    Article  PubMed  CAS  Google Scholar 

  48. Waigand J, Gross CM, Uhlich F, Kramer J, Tamaschke C, Vogel P, Luft FC, Dietz R. Elective stenting of carotid artery stenosis in patients with severe coronary artery disease. Eur Heart J 1998;19:1365–70.

    Article  PubMed  CAS  Google Scholar 

  49. Malek AM, Higashida RT, Phatouros CC, Lempert TE, Meyers PM, Smith WS, Dowd CF, Halbach VV. Stent angioplasty for cervical carotid artery stenosis in high-risk symptomatic NASCET-ineligible patients. Stroke 2000;31:3029–33.

    PubMed  CAS  Google Scholar 

  50. Yadav JS, Wholey MH, Kuntz RE, P Fayad, Katzen BT, Mishkel GJ, Bajwa TK, Whitlow P, Strickman NE, Jaff MR, Popma JJ, Snead DB, Cutlip DE, Firth BG, Ouriel K. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N Engl J Med 2004;351:1493–501.

    Article  PubMed  CAS  Google Scholar 

  51. Gray WA, Hopkins LN, Yadav S, Davis T, Wholey M, Atkinson R, Cremonesi A, Fairman R, Walker G, Verta P, Popma J, Virmani R, Cohen DJ. Protected carotid stenting in high-surgical-risk patients: the ARCHeR results. J Vasc Surg 2006;44:258–68.

    Article  PubMed  Google Scholar 

  52. Coward LJ, Featherstone RL, Brown MM. Safety and efficacy of endovascular treatment of carotid artery stenosis compared with carotid endarterectomy: a Cochrane systematic review of the randomized evidence. Stroke 2005;36:905–11.

    Article  PubMed  Google Scholar 

  53. Al-Mubarak N, Roubin GS, Gomez CR, Liu MW, Terry J, Lyer SS, Vitek JJ. Carotid artery stenting in patients with high neurologic risks. Am J Cardiol 1999;83:1411–3, A8–9.

    Article  PubMed  CAS  Google Scholar 

  54. Ringleb P, Kunze A, Allenberg JR, Hennerici M, Jansen O, Maurer PC, Zeumer H, Hacke W. Evaluation of stent-protected angioplasty for theray of symptomatic stenoses of the carotid artery. SPACE and other randomized trials. Nervenarzt 2003;74:482–8.

    PubMed  CAS  Google Scholar 

  55. Ringleb PA, Kunze A, Allenberg JR, Hennerici MG, Jansen O, Maurer PC, Zeumer H, Hacke W. The stent-supported percutaneous angioplasty of the carotid artery vs. endarterectomy trial. Cerebrovasc Dis 2004;18:66–8.

    Article  PubMed  CAS  Google Scholar 

  56. Brown MM, Rogers J, Bland JM. Endovascular versus surgical treatment in patients with carotid stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomised trial. Lancet 2001;357:1729–37.

    Article  Google Scholar 

  57. Liakishev AA. Protected carotid-artery stenting versus endarterectomy in high-risk patients. Results of SAPPHIRE trial. Kardiologiia 2004;44:76.

    PubMed  CAS  Google Scholar 

  58. Mas JL, Chatellier G, Beyssen B, Branchereau A, Moulin T, Becquemin JP, Larrue V, Lievre M, Leys D, Bonneville JF, Watelet J, Pruvo JP, Albucher JF, Viguier A, Piquet P, Garnier P, Viader F, Touze E, Giroud M, Hosseini H, Pillet JC, Favrole P, Neau JP, Ducrocq X. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 2006;355:1660–71.

    Article  PubMed  CAS  Google Scholar 

  59. Ringleb PA, Allenberg J, Bruckmann H, Eckstein HH, Fraedrich G, Hartmann M, Hennerici M, Jansen O, Klein G, Kunze A, Marx P, Niederkorn K, Schmiedt W, Solymosi L, Stingele R, Zeumer H, Hacke W. 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet 2006;368:1239–47.

    Article  PubMed  CAS  Google Scholar 

  60. Stingele R, Berger J, Alfke K, Eckstein HH, Fraedrich G, Allenberg J, Hartmann M, Ringleb PA, Fiehler J, Bruckmann H, Hennerici M, Jansen O, Klein G, Kunze A, Marx P, Niederkorn K, Schmiedt W, Solymosi L, Zeumer H, Hacke W. Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study. Lancet Neurol 2008;7:216–22.

    Article  PubMed  Google Scholar 

  61. Wittkugel O, Gbadamosi J, Rosenkranz M, Fiehler J, Zeumer H, Grzyska U. Long-term outcome after angioplasty of symptomatic internal carotid artery stenosis with and without stent. Neuroradiology 2008;50:243–9.

    Article  PubMed  CAS  Google Scholar 

  62. Eckert B, Zeumer H. Editorial comment – Carotid artery stenting with or without protection devices? Strong opinions, poor evidence! Stroke 2003;34:1941–3.

    Article  PubMed  Google Scholar 

  63. Cremonesi A, Manetti R, Setacci F, Setacci C, Castriota F. Protected carotid stenting: clinical advantages and complications of embolic protection devices in 442 consecutive patients. Stroke 2003;34:1936–41.

    Article  PubMed  Google Scholar 

  64. Kastrup A, Skalej M, Krapf H, Nagele T, Dichgans J, Schulz JB. Early outcome of carotid angioplasty and stenting versus carotid endarterectomy in a single academic center. Cerebrovasc Dis 2003;15:84–9.

    Article  PubMed  Google Scholar 

  65. Tan WA, Bates MC, Wholey MH. Cerebral protection systems for distal emboli during carotid artery interventions. J Interv Cardiol 2001;14:465–74.

    Article  PubMed  CAS  Google Scholar 

  66. Cloft HJ. Distal protection: maybe less than you think. AJNR Am J Neuroradiol 2008;29:407–8.

    Article  PubMed  CAS  Google Scholar 

  67. Wittkugel O, Fiehler J, Koch C, Eckert B, Kilic E, Frahm M, Zeumer H. Endovascular treatment of internal carotid artery stenosis: effect of primary stent application on debris particle release in human cadaveric specimens. Radiology 2003;229:855–60.

    Article  PubMed  Google Scholar 

  68. Rosenkranz M, Fiehler J, Niesen W, Waiblinger C, Eckert B, Wittkugel O, Kucinski T, Rother J, Zeumer H, Weiller C, Sliwka U. The amount of solid cerebral microemboli during carotid stenting does not relate to the frequency of silent ischemic lesions. AJNR Am J Neuroradiol 2006;27:157–61

    PubMed  CAS  Google Scholar 

  69. Thomalla G, Kruetzelmann A, Siemonsen S, Gerloff C, Rosenkranz M, Rother J, Fiehler J. Clinical and tissue response to intravenous thrombolysis in tandem internal carotid artery/middle cerebral artery occlusion: an MRI study. Stroke 2008;39:1616–8.

    Article  PubMed  Google Scholar 

  70. Einsiedel-Lechtape H. Secondary emboli: a frequent sequela of complete extracranial internal carotid artery occlusion. Neuroradiology 1978;16:96–100.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Oliver Wittkugel MD.

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* Dedicated to Professor Hermann Zeumer, MD, on the occasion of his 65th birthday and his retirement.

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Wittkugel, O. Acute and Prophylactic Endovascular Treatment of Internal Carotid Artery Stenosis*. Clin Neuroradiol 19, 31–37 (2009). https://doi.org/10.1007/s00062-009-8037-9

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