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Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines

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Abstract

Citral, 3,7-dimethyl-2,6-octadienal, is a key component of the essential oils extracted from several lemon-scented herbal plants. It has been demonstrated to be an effective antifungal agent and in recent years, to have antiproliferative effect in certain tumor cell lines: thus citral could be a potential anticancer drug. In this study, we investigated the effect of citral on the proliferation of pancreatic cell tumor lines (MIA PaCa-2 cells) and human B-lymphoma (DeFew cells). To analyze which part of the molecule is pivotal for the activity, we also studied the effect of several citral related compounds, in particular focusing on some chemical aspects of the terpenic scaffold. The in vitro studies revealed the significant cytotoxic activity of some of the tested compounds.

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Acknowledgements

Thanks are due to university of Salerno for financial support.

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Authors and Affiliations

  1. Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, 132, Fisciano, SA, 84084, Italy

    Antonia Di Mola, Vincenzo De Feo, Maria Pascale, Rita Patrizia Aquino & Paolo De Caprariis

  2. Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, Fisciano, SA, 84084, Italy

    Antonio Massa

  3. Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”, Università di Salerno, Via Allende, Baronissi, SA, 84084, Italy

    Anna Basile

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  1. Antonia Di Mola
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  2. Antonio Massa
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  3. Vincenzo De Feo
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  4. Anna Basile
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  5. Maria Pascale
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  6. Rita Patrizia Aquino
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  7. Paolo De Caprariis
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Correspondence to Antonia Di Mola or Paolo De Caprariis.

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Di Mola, A., Massa, A., De Feo, V. et al. Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines. Med Chem Res 26, 631–639 (2017). https://doi.org/10.1007/s00044-017-1779-z

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  • DOI: https://doi.org/10.1007/s00044-017-1779-z

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