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Immunomodulatory effects of diarylpentanoid analogues of curcumin

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Abstract

Diarylpentanoid analogues of curcumin are known for their various pharmacological activities which include the inhibition of inflammatory mediators and are good candidates as immunomodulators that could be useful in the treatment of inflammation. In the work described here, seventeen diarylpentanoid curcumin analogues were assessed for their inhibitory effects on the reactive oxygen species (ROS) production, chemotaxis and phagocytosis of human neutrophils. ROS production was evaluated using luminol and lucigenin-based chemiluminesence assay, while inhibition of isolated polymorphonuclear neutrophils chemotaxis and phagocytosis abilities were investigated using the Boyden chamber technique and the Phagotest kit, respectively. Two of the analogues, compounds 1e and 2e, which contain the 2-methyl-4(N-ethyl-N-ethylacetonitrile)aniline functional group, were active in all the assays performed. Moreover, analogues containing heteroatoms (1a, 1e, 2c, 2d, 2e, 3a and 3c) were active in suppressing the neutrophil phagocytic activity. The information obtained gave new insight into curcumin analogues with the potential to be developed as new immunomodulators.

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Acknowledgments

The authors would like to thank the Ministry of Science, Technology and Innovation, Malaysia for the financial support (Grants No.: 02-01-02-SF0510 and 02-01-02-SF0016) and Dr. Azmath Jaleel for his help in editing the manuscript.

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Authors and Affiliations

  1. Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd. Aziz, 50300, Kuala Lumpur, Malaysia

    Syed Nasir Abbas Bukhari, Ibrahim Jantan, Endang Kumolosasi & Malina Jasamai

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  1. Syed Nasir Abbas Bukhari
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  2. Ibrahim Jantan
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  3. Endang Kumolosasi
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  4. Malina Jasamai
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Correspondence to Malina Jasamai.

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Bukhari, S.N.A., Jantan, I., Kumolosasi, E. et al. Immunomodulatory effects of diarylpentanoid analogues of curcumin. Med Chem Res 24, 3405–3411 (2015). https://doi.org/10.1007/s00044-015-1387-8

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  • DOI: https://doi.org/10.1007/s00044-015-1387-8

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