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Chemical constituents from Chorisia chodatii flowers and their biological activities

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Abstract

From the flowers of Chorisia chodatii Hassl. (family: Bombacaceae), seventeen compounds were isolated and identified, including: two sterols, β-sitosterol (1) and β-sitosterol 3-O-β-D-glucopyranoside (10); two furanoids, 5-hydroxymethyl furfural (3) and (3R,4R,5S)-3,4-dihydroxy-5-methyl-dihydrofuran-2-one (12); two coumarins, scopoletin (8) and aesculetin (9); four phenolic acids and esters, ethyl vanillate (4), vanillic acid (5), protocatechuic acid ethyl ester (6) and p-hydroxy benzoic acid (7); five flavonoids, kaempferol 3-O-β-D-(6″-acetyl)-glucopyranoside (13), kaempferol 3-O-β-D-(6″-E-p-coumaroyl)-glucopyranoside (14), kaempferol 3-O-β-D-glucopyranoside (15), luteolin 7-O-β-D-glucopyranoside (16) and apigenin 7-O-neohesperidoside (17), in addition to mono-octyl phthalate (2) and succinic acid (11). All the isolated metabolites were reported for the first time from this plant, and among them, compounds (3), (4), (6), (7), (12) and (13) were isolated for the first time from family Bombacaceae. Besides, this is the first report for isolation of (2) in a pure form from a natural source. These phytochemical data revealed important chemotaxonomic value and may broaden the use of this plant in future phytotherapy. Moreover, all of the obtained phytocompounds were evaluated for their DPPH free radical scavenging properties and cytotoxic activities against the human lung cancer cell line A549.

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Acknowledgments

The authors are grateful for access to the superconducting NMR instrument and ESI-MS at the Analytical Center of Molecular Medicine, the Analysis Center of Life Science and the Natural Science Center for Basic Research and Development of the Graduate School of Biomedical and Health Sciences, Hiroshima University.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Pharmacognosy Department, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt

    John Refaat, Mamdouh N. Samy, Samar Y. Desoukey & Mohamed S. Kamel

  2. Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71515, Egypt

    Mahmoud A. Ramadan

  3. Pharmacognosy Department, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Sachiko Sugimoto & Katsuyoshi Matsunami

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  1. John Refaat
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  5. Sachiko Sugimoto
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Correspondence to John Refaat.

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Refaat, J., Samy, M.N., Desoukey, S.Y. et al. Chemical constituents from Chorisia chodatii flowers and their biological activities. Med Chem Res 24, 2939–2949 (2015). https://doi.org/10.1007/s00044-015-1342-8

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