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Co(II), Ni(II), Cu(II) and Zn(II) Complexes of 4-(4-cyanobenzylideneamino)-3-mercapto-5-oxo-1,2,4-triazine: synthesis, characterization and biological studies

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Abstract

A new series of metal complexes have been synthesized with an imine 4-(4-cyanobenzylideneamino)-3-mercapto-5-oxo-1,2,4-triazine which has been derived by the condensation of 4-cyanobenzaldehyde and 4-amino-3-mercapto-5-oxo-1,2,4-triazine. Different techniques like IR, 1H NMR, electronic spectroscopy, fluorescence, ESR, thermal, conductivity and magnetic measurements were used to investigate the structural features of the synthesized compounds. Based on spectral and thermal techniques, octahedral geometry has been proposed for Co(II), Ni(II) and Zn(II) complexes and square planar for Cu(II) complexes. All the synthesized metal complexes show enhancement in fluorescence intensity in comparison to the ligand. The newly synthesized ligand and metal complexes were also screened for their antimicrobial activities against some bacterial and fungal strains to assess their inhibiting potential in vitro. The activities shown by these complexes were compared with ligand and also with standard drugs. The molar conductivity values indicate that the complexes are non-electrolytes.

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Acknowledgments

One of the authors (Sunita Raparia) is highly thankful to HSCST (Haryana State Council for Science and Technology) for providing Junior Research Fellowship (JRF) and Department of Chemistry, Kurukshetra University Kurukshetra for providing necessary laboratory facilities to carry out this research work. Authors are also thankful to SAIF, IIT Bombay for ESR analysis, SAIF, Panjab University Chandigarh for providing far IR data and IIC, IIT Roorkee for magnetic moment data.

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Authors and Affiliations

  1. Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119, India

    Kiran Singh & Sunita Raparia

  2. Department of Microbiology, Kurukshetra University, Kurukshetra, 136 119, India

    Parveen Surain

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  1. Kiran Singh
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  2. Sunita Raparia
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  3. Parveen Surain
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Correspondence to Kiran Singh.

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Singh, K., Raparia, S. & Surain, P. Co(II), Ni(II), Cu(II) and Zn(II) Complexes of 4-(4-cyanobenzylideneamino)-3-mercapto-5-oxo-1,2,4-triazine: synthesis, characterization and biological studies. Med Chem Res 24, 2336–2346 (2015). https://doi.org/10.1007/s00044-014-1298-0

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  • DOI: https://doi.org/10.1007/s00044-014-1298-0

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