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Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst

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Abstract

2-(2-Chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives 5a–m were synthesized in good yield using conventional as well as microwave heating conditions in presence of l-proline as a catalyst. Synthetic conditions were optimized using an orthogonal array system of Taguchi’s design. The structure of synthesized quinazolinone compounds 5a–m was established with the help of physico-chemical analysis and various spectroscopic techniques like FT-IR, mass, 1H-NMR and 13C-NMR. Further, all the synthesized compounds were screened for their antimicrobial (antibacterial, antifungal and antimalarial) activities. The results of antimicrobial screening showed that compounds 4g, 4j, 4m, 5e and 5g have good activity against bacterial species, whereas compounds 4d, 4g, 4m, 5b, 5d and 5g have good activity against malaria pathogen. In addition to this, compounds 4i, 4j and 4m exhibited good to moderate activity against fungal strains.

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Acknowledgments

We gratefully acknowledge the Director, ARIBAS and C. V. M. for providing all the necessary research facilities. We also thanks to Dr. Saurabh S. Soni, Assistant professor, Department of Chemistry, S. P. University for providing scientific microwave oven facility. We are also obliged by Director, SICART for providing analysis facilities.

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Authors and Affiliations

  1. Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, Affiliated to Sardar Patel University, New Vallabh Vidyanagar, 388121, Gujarat, India

    Ritu Dixit & Hemal Mehta

  2. V. P. & R. P. T. P. Science College, Vallabh Vidyanagar, Anand, Gujarat, India

    Bharat Dixit

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  1. Ritu Dixit
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  2. Hemal Mehta
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  3. Bharat Dixit
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Correspondence to Ritu Dixit.

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Dixit, R., Mehta, H. & Dixit, B. Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst. Med Chem Res 24, 773–786 (2015). https://doi.org/10.1007/s00044-014-1116-8

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  • DOI: https://doi.org/10.1007/s00044-014-1116-8

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