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Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives

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Abstract

A new series of 7-O-substituted pyridyl-4-methyl coumarin derivatives were synthesized and characterized based on their spectral data. All the target compounds were evaluated for their in vitro antifungal activity against eight important fungal pathogens. This study showed that the introduction of the substituted pyridyl moiety at the 7-hydroxy position of coumarin could enhance the antifungal activities. It also indicated that a bulky substituent was not beneficial to the antifungal activity of those coumarin derivatives.

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Acknowledgments

This work was supported by the Pharmaceutical Education research project of Chinese Association of Higher Medical Education Professional Committee (Grant No. ZD201220), the Creativity and Innovation Training Program of Second Military Medical University (Grant No. ZD2008008), and the Shanghai Leading Academic Discipline Project (No. B906).

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Authors and Affiliations

  1. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai, 200433, People’s Republic of China

    Xiaoyun Chai, Shichong Yu, Dazhi Zhang, Qiuye Wu & Qingyan Sun

  2. Center for Laboratory Teaching, School of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai, 200433, People’s Republic of China

    Xiaoyan Wang

  3. Pharmacy Team, Administrative Brigade of Postgraduate, Second Military Medical University, Zhengtong Road 41, Shanghai, 200433, People’s Republic of China

    Nan Wang & Zhanzhou Zhu

  4. Drug Research Center, School of Pharmacy, Second Military Medical University, Guohe Road 325, Shanghai, 200433, People’s Republic of China

    Yongbing Cao

Authors
  1. Xiaoyun Chai
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  2. Shichong Yu
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  3. Xiaoyan Wang
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  4. Nan Wang
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  5. Zhanzhou Zhu
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  6. Dazhi Zhang
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  7. Qiuye Wu
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  8. Yongbing Cao
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  9. Qingyan Sun
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Corresponding author

Correspondence to Qingyan Sun.

Additional information

Xiaoyun Chai and Shichong Yu contributed equally to this study.

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Chai, X., Yu, S., Wang, X. et al. Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives. Med Chem Res 22, 4654–4662 (2013). https://doi.org/10.1007/s00044-013-0470-2

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  • DOI: https://doi.org/10.1007/s00044-013-0470-2

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