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Synthesis of new quinoline-2-pyrazoline-based thiazolinone derivatives as potential antimicrobial agents

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Abstract

A series of 2-(5-(2-chloro-6-methylquinolin-3-yl)-3-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)ones (4a–l) were synthesized and characterized by IR, 1H NMR, 13C NMR, and mass spectra. All the synthesized compounds were tested for their in vitro antimicrobial activity against Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442), Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), and Aspergillus clavatus (MTCC 1323) by serial broth dilution. Compounds 4e, 4f, 4g, 4i, 4j, and 4l were the most distinctive derivatives identified in present study because of their remarkable in vitro antimicrobial potency.

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Acknowledgments

The authors are thankful to the Head, Department of Chemistry, Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, for providing laboratory facilities.

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  1. Division of Medicinal Chemistry, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar, 364 002, India

    N. C. Desai, V. V. Joshi & K. M. Rajpara

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  1. N. C. Desai
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  2. V. V. Joshi
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  3. K. M. Rajpara
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Correspondence to N. C. Desai.

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Desai, N.C., Joshi, V.V. & Rajpara, K.M. Synthesis of new quinoline-2-pyrazoline-based thiazolinone derivatives as potential antimicrobial agents. Med Chem Res 22, 3663–3674 (2013). https://doi.org/10.1007/s00044-012-0377-3

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