Abstract
In vitro antibacterial activity of a phytoconstituent, entagenic acid isolated from the seed kernel of Entada pursaetha DC was screened against both gram negative and gram positive bacteria. The entagenic acid showed the high antibacterial activity against B. cereus and B. subtilis with minimal inhibitory concentration of 200 μg ml−1 and possesses better glucosamine-6-phosphate synthase inhibition in molecular docking studies with minimum docking energy −9.22 kJ mol−1, binding energy −9.28 kJ mol−1 and inhibition constant 1.57e−007. The inhibition constant of streptomycin was 3.86e−005.
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Acknowledgments
The authors are grateful to National Educational Society, Shimoga, Karnataka. Sri N.V. Hegde, President, Nitte Education Trust, Nitte, Karnataka. Dr. S.Y. Kulkarni, Principal, NMAMIT, Nitte. Dr. Vaman Rao, HOD, Department of Biotechnology, NMAMIT, Nitte, Karnataka and Registrar, Kuvempu University, Shankaraghatta, Karnataka, India.
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Vidya, S.M., Krishna, V., Manjunatha, B.K. et al. Antibacterial and molecular docking studies of entagenic acid, a bioactive principle from seed kernel of Entada pursaetha DC. Med Chem Res 21, 1016–1022 (2012). https://doi.org/10.1007/s00044-011-9614-4
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DOI: https://doi.org/10.1007/s00044-011-9614-4