Abstract
Objectives
This study explored previously little-known cancer mortality trends with a focus on changes with age and sex differences in 16 countries.
Methods
Time series age–sex-specific cancer mortality, deaths from all causes, and population data were used for statistical description.
Results
The cancer mortality rate (CMR) peaked and declined with age in 11 countries. CMRs appeared to peak earlier and decline more dramatically in earlier time periods rather than later periods and for males rather than females. CMR peaking could have possibly been historically delayed. Moreover, “percentage of deaths from cancer” (PDC) in all 16 countries plunged after about age 60. Middle-aged women may have higher CMRs than men. Premenopausal women may have higher PDCs than postmenopausal women.
Conclusions
The findings make significant contributions to the literature, though their interpretation and application have limitations due to data quality and availability. Future research should explore if and how the findings apply to other countries and time periods. Public health practitioners and policy makers should consider age–sex-specific strategies for more effective cancer control.
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References
AIHW (Australia Institute of Health and Welfare) (2015a) Custom Tabulation. Deaths Database, 1968–2012: Deaths of all causes, cancer mortality, and population by age groups (85–89, 90–94, 95–99, 100 and over) and sex (total, male and female)
AIHW (2015b) General record of incidence of mortality workbooks 2012. http://www.aihw.gov.au/deaths/grim-books. Accessed 12 April 2016
AIHW (2015c) Australian cancer incidence and mortality (ACIM) books, all cancers combined. http://www.aihw.gov.au/acim-books. Accessed 12 April 2016
Althuis MD, Dozier JM, Anderson WF et al (2005) Global trends in breast cancer incidence and mortality 1973–1997. Int J Epidemiol 34(2):405–412. doi:10.1093/ije/dyh414
Andersen SL, Terry DF, Wilcox MA, Babineau T, Malek K, Perls TT (2005) Cancer in the oldest old. Mech Ageing Dev 126(2):263–267
Balducci L, Ershler WB (2005) Cancer and ageing: a nexus at several levels. Nat Rev Cancer 5:655–662. doi:10.1038/nrc1675
Bray F, Znaor A, Cueva P, Korir A, Swaminathan R, Ullrich A, Wang SA, Parkin DM (2015) Chapter 5. Quality control at the population-based cancer registry. Planning and developing population-based cancer registration in low- and middle-income settings. IARC Technical Publication No. 43. http://www.iarc.fr/en/publications/pdfs-online/treport-pub/treport-pub43. Accessed 12 April 2016
Cancer Research UK (2015) Cancer causes more than one in four of all deaths, 2011, UK. Cancer mortality statistics. http://www.cancerresearchuk.org/health-professional/cancer-mortality-statistics. Accessed 12 April 2016
Coleman MP et al (2011) Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data. Lancet 377(9760):127–138
Cook M, McGlynn KA, Devesa SS, Freedman ND, Anderson WF (2011) Sex disparities in cancer mortality and survival. Cancer Epidemiol Biomark Prev 20(8):1629. doi:10.1158/1055-9965.EPI-11-0246
de Magalhães JP (2013) How ageing processes influence cancer. Nat Rev Cancer 13:357–365. doi:10.1038/nrc3497
de Rijke JM, Schouten LJ, Hillen HFP, Kiemeney L, Coebergh JW, van den Brandt PA (2001) Cancer in the very elderly Dutch population. Cancer 89:1121–1133. doi:10.1002/1097-0142(20000901)89:5<1121:AID-CNCR22>3.0.CO;2-G
Dix D (2014) The female health-survival advantage: paradox unwarranted. Int J Public Health 59:213
Finkel T, Serrano M, Blasco MA (2007) The common biology of cancer and ageing. Nature 448(7155):767–774
Frank SA (2007) Dynamics of cancer. Princeton University Press, Princeton
Harding C, Pompei F, Wilson R (2012) Peak and decline in cancer incidence, mortality, and prevalence at old ages. Cancer 118:1371–1386. doi:10.1002/cncr.26376
Hirte L, Nolte E, Bain C, McKee M (2007) Breast cancer mortality in Russia and Ukraine 1963–2002: an age-period-cohort analysis. Int J Epidemiol 36(4):900–906. doi:10.1093/ije/dym066
Jasilionis D, Smailyte G, Vincerzevskiene I, Shkolnikov VM (2015) Educational differentials in cancer mortality and avoidable deaths in Lithuania, 2001–2009: a census-linked study. Int J Public Health 60(8):919–926
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90. doi:10.3322/caac.20107
Leung CC, Lam TH, Yew WW et al (2011) Lower lung cancer mortality in obesity Int. J. Epidemiol 40(1):174–182. doi:10.1093/ije/dyq134
Maruthappu M, Watson RA, Watkins J, Williams C, Zeltner T, Faiz O, Ali R, Atun R (2016) Unemployment, public-sector healthcare expenditure and colorectal cancer mortality in the European Union: 1990–2009. Int J Public Health 61:119–130
NCC (National Cancer Center) (2015) Japan. Vital statistics in Japan, tabulated by cancer information service, cancer mortality from vital statistics in Japan (1958–2013). http://ganjoho.jp/en/professional/statistics/table_download.html. Accessed 12 April 2016
Ortman JM, Velkoff VA, Hogan H (2014) An aging nation: the older population in the United States. https://www.census.gov/prod/2014pubs/p25-1140.pdf. Accessed 12 April 2016
OuYang P-Y et al (2015) The significant survival advantage of female sex in nasopharyngeal carcinoma: a propensity-matched analysis. Br J Cancer 112(9):1554–1561. doi:10.1038/bjc.2015.70
PSOSJ (2015b) Deaths by causes (the list of three-character categories), sex and age: Japan. 2012 data available at https://www.e-stat.go.jp/SG1/estat/GL76050103.do;jsessionid=6XWMTJWfHY771R4tBpydJ6PGQq2lfTxs24zt5K43ny2fKL2cWcSx!1533061118!244457392?_toGL76050103_&listID=000001108739&forwardFrom=GL76050101, 2011 data at http://www.e-stat.go.jp/SG1/estat/ListE.do?lid=000001101884, 2010 Data at http://www.e-stat.go.jp/SG1/estat/ListE.do?lid=000001101825. Accessed 12 April 2016
PSOSJ (Portal Site of Official Statistics in Japan) (2015a) Specified report of vital statistics in FY2014. Table 1-1. Trends in deaths by sex and age (5-years age groups), 1955–2013. http://www.e-stat.go.jp/SG1/estat/GL38020103.do?_toGL38020103_&listID=000001128914&requestSender=estat. Accessed 12 April 2016
Qu Y, Chen H, Gu W et al (2015) Age-dependent association between sex and renal cell carcinoma mortality: a population-based analysis. Sci Rep 5:9160. doi: 10.1038/srep09160. http://www.nature.com/srep/2015/150317/srep09160/abs/srep09160.html#supplementary-information. Accessed 12 April 2016
Quaresma M et al (2014) 40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study. Lancet 385(9974):1206–1218. doi:10.1016/S0140-6736(14)61396-9
Siegel RL, Miller KD, Jemal A (2015) Cancer statistics. CA Cancer J Clin 65(1):5–29
Smith DW (1996) Cancer mortality at very old ages. Cancer 77(7):1367–1372
Stanta G, Campagner L, Cavallieri F, Giarelli L (1997) Cancer of the oldest old. What we have learned from autopsy studies. Clin Geriatr Med 13:55–68
Statistics Canada (2015a) Table 102-0551: Deaths and mortality rate, by selected grouped causes, age group and sex, Canada, annual. http://www5.statcan.gc.ca/cansim/pick-choisir?lang=eng&p2=33&id=1020551. Accessed 12 April 2016
Statistics Canada (2015b) Canadian Vital Statistics Custom Tabulation, Deaths Database, 2000–2011: Deaths of all causes, cancer mortality, and population by age groups (90–94, 95–99, 100 and over) and sex (total, male and female)
Statistics Japan (2015) Japan statistical yearbook 2015. Table 2–7 population by age. http://www.stat.go.jp/english/data/nenkan/1431-02.htm. Accessed 12 April 2016
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87–108. doi:10.3322/caac.21262
UKONS (United Kingdom Office of National Statistics) (2014) Mortality statistics: deaths registered in 2013 Table 5.2; Table PP04 2011 census; Table PP05 2011 census; Table PP06 2011 census. http://www.ons.gov.uk/ons/datasets-and-tables/index.html. Accessed 12 April 2016
US Census Bureau (2015) Annual estimates of the resident population by single year of age and sex for the United States: April 1, 2010 to July 1, 2013. http://factfinder.census.gov/faces/tableservices/jsf/pages/productview.xhtml?src=bkmk. Accessed 12 April 2016
USCDC (2014b) US cancer statistics: 1999–2011 mortality, wonder online database. United States Department of Health and Human Services. http://wonder.cdc.gov/CancerMort-v2011.html. Accessed 12 April 2016
USCDC (2014c) National Center for Health Statistics. Underlying cause of death 1999-2013 on CDC WONDER online database released 2015. http://wonder.cdc.gov/ucd-icd10.html. Accessed 12 April 2016
USCDC (United States Centers for Disease Control and Prevention) (2014a) National vital statistics system. 12/31/2014. LCWK1. Deaths, percent of total deaths, and death rates for the 15 leading causes of death in 5-year age groups, by race and sex: United States, 2013. http://www.cdc.gov/nchs/data/dvs/LCWK1_2013.pdf. Accessed 12 April 2016
Van Oyen H, Nusselder W, Jagger C, Kolip P, Cambois E, Robine J (2013) Gender differences in healthy life years within the EU: an exploration of the “health-survival” paradox. Int J Public Health 58(1):143–155. doi:10.1007/s00038-012-0361-1. Accessed 12 April 2016
WHO (World Health Organization) (2015) WHO mortality database. Cause of death query online. http://apps.who.int/healthinfo/statistics/mortality/causeofdeath_query. Accessed 12 April 2016
Yang Y, Li T, Nielsen ME (2012) Aging and cancer mortality: dynamics of change and sex differences. Exp Gerontol 47(9):695–705
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We thank Xinyu Liang for his research assistance.
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Liu, L., Liu, K. Age-specific cancer mortality trends in 16 countries. Int J Public Health 61, 751–763 (2016). https://doi.org/10.1007/s00038-016-0858-0
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DOI: https://doi.org/10.1007/s00038-016-0858-0